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Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed?

作者信息

Van Noorden Richard

出版信息

Nature. 2023 Jul;619(7970):454-458. doi: 10.1038/d41586-023-02299-w.

DOI:10.1038/d41586-023-02299-w
PMID:37464079
Abstract
摘要

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Tranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery.氨甲环酸预防剖宫产产后出血
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Procrastination and inconsistency: Expressions of concern for publications with compromised integrity.拖延和不一致:对有失诚信的出版物的关注表现。
Account Res. 2024 Dec;31(3):196-209. doi: 10.1080/08989621.2022.2112572. Epub 2022 Aug 18.
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Tocolytics for delaying preterm birth: a network meta-analysis (0924).用于延迟早产的保胎药物:一项网状荟萃分析 (0924)。
药学研究中严谨性的重要性:挑战与解决方案。
Res Social Adm Pharm. 2025 May;21(5):424-430. doi: 10.1016/j.sapharm.2025.02.005. Epub 2025 Feb 7.
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Public engagement with research reproducibility.公众对研究可重复性的参与。
PLoS Biol. 2024 Dec 11;22(12):e3002953. doi: 10.1371/journal.pbio.3002953. eCollection 2024 Dec.
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Safety reporting in trials on glaucoma interventions registered in ClinicalTrials.gov and corresponding publications.临床试验中青光眼干预措施的安全性报告在 ClinicalTrials.gov 注册及相应出版物中的体现。
Sci Rep. 2024 Nov 12;14(1):27762. doi: 10.1038/s41598-024-79394-z.
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[Childhood vaccine hesitancy and COVID-19 in Brazil: expanding the analysis from the perception of health professionals].[巴西儿童疫苗犹豫与新冠疫情:拓展对卫生专业人员认知的分析]
Cad Saude Publica. 2024 Sep 9;40(8):e00068824. doi: 10.1590/0102-311XPT068824. eCollection 2024.
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Preoperative statins in cardiac surgery: a tale of small study bias or 'the truth, and nothing but the truth'.心脏手术中的术前他汀类药物治疗:小样本研究偏差的故事还是“真相,全部的真相” 。
Cochrane Database Syst Rev. 2024 Jul 22;7(7):ED000167. doi: 10.1002/14651858.ED000167.
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'Trustworthy' systematic reviews can only result in meaningful conclusions if the quality of randomized clinical trials and the certainty of evidence improves: an update on the 'trustworthy' living systematic review project.只有当随机临床试验的质量和证据的确定性得到改善时,“可信”的系统评价才能得出有意义的结论:“可信”的实时系统评价项目的最新情况
J Man Manip Ther. 2024 Aug;32(4):363-367. doi: 10.1080/10669817.2024.2377490. Epub 2024 Jul 11.
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How to fight fake papers: a review on important information sources and steps towards solution of the problem.如何打击假论文:重要信息来源及解决问题步骤综述。
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Trust me: You can't trust everything that you read.相信我:你不能相信你读到的所有东西。
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Cochrane Database Syst Rev. 2022 Aug 10;8(8):CD014978. doi: 10.1002/14651858.CD014978.pub2.
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Ivermectin for preventing and treating COVID-19.伊维菌素预防和治疗 COVID-19。
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Tranexamic acid for the prevention of postpartum hemorrhage in women undergoing cesarean delivery: an updated meta-analysis.氨甲环酸预防剖宫产产后出血的疗效:一项更新的荟萃分析。
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When beauty is but skin deep: dealing with problematic studies in systematic reviews.当美丽只是肤浅的:应对系统评价中的问题研究。
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Cochrane Database Syst Rev. 2018 Aug 3;8(8):CD006614. doi: 10.1002/14651858.CD006614.pub3.
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Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial.氨甲环酸早期给药对产后出血妇女死亡率、子宫切除术和其他并发症的影响(WOMAN):一项国际、随机、双盲、安慰剂对照试验。
Lancet. 2017 May 27;389(10084):2105-2116. doi: 10.1016/S0140-6736(17)30638-4. Epub 2017 Apr 26.
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Does tranexamic acid prevent postpartum haemorrhage? A systematic review of randomised controlled trials.氨甲环酸能否预防产后出血?一项随机对照试验的系统评价。
BJOG. 2016 Oct;123(11):1745-52. doi: 10.1111/1471-0528.14267. Epub 2016 Aug 24.