Pharmaceutical Research Center, Health Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Vice-Chancellor for Food and Drug Affairs, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Curr Top Med Chem. 2023;23(23):2242-2265. doi: 10.2174/1568026623666230718163613.
While food safety issues are attracting public concern due to their detrimental effects on human health, monitoring livestock health is urgently needed to diagnose animal diseases at an early stage by applying proper treatments, controlling, and preventing outbreaks, particularly in resource- limited countries. In addition, unhealthy farms are not only a threat to livestock but also to human lives. The available diagnostic techniques for the detection of key health threats within both the food and livestock sectors require labor-intensive and time-consuming experimental procedures and sophisticated and expensive instruments. To tackle this issue, optical biosensing strategies have been incorporated into point-of-care (POC) systems, offering real-time monitoring, field-deployable, and low-cost devices, which help make on-the-spot decisions. This review aims to discuss the recent cutting-edge research on POC optical biosensing platforms for on-farm diagnosis of animal diseases and on-site detection of animal-derived food-borne contaminants, including pathogens, antibiotics, and mycotoxins. Moreover, this review briefly presents the basic knowledge of various types of optical biosensors and their development using various recent strategies, including nanomaterial combinations, to enhance their performance in POC tests. This review is expected to help scientists to understand the evolution and challenges in the development of point-of-care biosensors for the food and livestock industry, benefiting global healthcare.
虽然食品安全问题因其对人类健康的有害影响而引起公众关注，但监测牲畜健康对于通过适当的治疗来早期诊断动物疾病、控制和预防疫情至关重要，特别是在资源有限的国家。此外，不健康的农场不仅对牲畜构成威胁，也对人类生命构成威胁。现有的用于检测食品和牲畜部门中关键健康威胁的诊断技术需要劳动密集型和耗时的实验程序以及复杂和昂贵的仪器。为了解决这个问题，光学生物传感策略已被纳入即时检测（POC）系统，提供实时监测、现场部署和低成本的设备，有助于做出现场决策。本综述旨在讨论用于农场动物疾病现场诊断和现场检测动物源性食源性污染物（包括病原体、抗生素和霉菌毒素）的即时检测光学生物传感平台的最新前沿研究。此外，本综述简要介绍了各种类型的光学生物传感器的基础知识及其使用各种最新策略的开发，包括纳米材料组合，以提高其在 POC 测试中的性能。预计本综述将帮助科学家了解即时检测生物传感器在食品和牲畜行业中的发展演变和挑战，从而有益于全球医疗保健。
