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黑种草籽()医学应用与药学前景。 你提供的原文中括号里内容缺失,请补充完整以便能准确翻译。

Black Seeds () Medical Application and Pharmaceutical Perspectives.

作者信息

Ferizi Rrahman, Ramadan Mohamed F, Maxhuni Qenan

机构信息

Premedical Department, Faculty of Medicine, University of Prishtina, 10000 Prishtine, Kosovo, Albania.

Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.

出版信息

J Pharm Bioallied Sci. 2023 Apr-Jun;15(2):63-67. doi: 10.4103/jpbs.jpbs_364_22. Epub 2023 Jun 8.

DOI:10.4103/jpbs.jpbs_364_22
PMID:37469646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10353664/
Abstract

Among the various medicinal plants, the black seed is emerging as a miracle herb with a rich historical background, as much research has revealed its wide spectrum of pharmacological potential. In this collection of literature, we have encountered and presented the preclinical treatment, as alternative medicine of in the prevention and treatment of various diseases, as well as those that continue to be discovered by contemporary actual scientific data. Research to date has confirmed the pharmacological potential of the seed of , its oil and extracts of some of its bioactive constituents, which possess remarkable pharmacological activity, and against a large spectrum of diseases, and it has been found that the use of black seed is relatively safe. Black Seed has been extensively studied for its biological activity and therapeutic potential and has been found to possess a broad spectrum of activities. Clinical trial investigations into the therapeutic effects of affect the hypoglycemic, hypolipidemic, and bronchodilator effects and have passed clinical trials and received the green light to allow the next stage of clinical trials toward therapeutic drug design. However, there is still room and multidimensional research needed for prospective clinical trials in certain groups of animals before they can be applied to humans as pharmaceutical therapies.

摘要

在各种药用植物中,黑种草作为一种有着丰富历史背景的神奇草药正在崭露头角,因为大量研究已揭示其具有广泛的药理潜力。在本系列文献中,我们遇到并介绍了其临床前治疗情况,它作为替代医学可用于预防和治疗各种疾病,以及当代实际科学数据不断发现的其他疾病。迄今为止的研究证实了黑种草籽、其油以及某些生物活性成分提取物的药理潜力,它们具有显著的药理活性,对多种疾病有效,并且发现使用黑种草相对安全。黑种草因其生物活性和治疗潜力已得到广泛研究,并且已发现它具有广泛的活性。对黑种草治疗效果的临床试验研究涉及降血糖、降血脂和支气管扩张作用,并且已通过临床试验并获批进入下一阶段针对治疗药物设计的临床试验。然而,在将其作为药物疗法应用于人类之前,在某些动物群体中进行前瞻性临床试验仍有空间且需要多维度研究。

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Thymoquinone induces apoptosis in bladder cancer cell via endoplasmic reticulum stress-dependent mitochondrial pathway.胸腺醌通过内质网应激依赖的线粒体途径诱导膀胱癌细胞凋亡。
Chem Biol Interact. 2018 Aug 25;292:65-75. doi: 10.1016/j.cbi.2018.06.013. Epub 2018 Jul 2.
2
Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects.黑孜然(黑种草)及其成分(百里醌):抗菌作用综述
Iran J Basic Med Sci. 2014 Dec;17(12):929-38.
3
Effects of the hydro-alcoholic extract of Nigella sativa on scopolamine-induced spatial memory impairment in rats and its possible mechanism.黑种草水醇提取物对东莨菪碱诱导的大鼠空间记忆损伤的影响及其可能机制。
Chin J Integr Med. 2015 Jun;21(6):438-44. doi: 10.1007/s11655-014-1742-5. Epub 2014 Mar 2.
4
Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males.黑种草籽对健康青春期男性的情绪、焦虑和认知有调节作用。
J Ethnopharmacol. 2014 Feb 27;152(1):156-62. doi: 10.1016/j.jep.2013.12.050. Epub 2014 Jan 8.
5
A review on therapeutic potential of Nigella sativa: A miracle herb.黑种草的治疗潜力综述:一种神奇的草药。
Asian Pac J Trop Biomed. 2013 May;3(5):337-52. doi: 10.1016/S2221-1691(13)60075-1.
6
Effect of aqueous and ethanolic extracts of Nigella sativa seeds on milk production in rats.黑种草籽水提取物和乙醇提取物对大鼠产奶量的影响。
J Acupunct Meridian Stud. 2013 Feb;6(1):18-23. doi: 10.1016/j.jams.2012.07.019. Epub 2012 Aug 11.
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Cancer chemopreventive potential of volatile oil from black cumin seeds, Nigella sativa L., in a rat multi-organ carcinogenesis bioassay.黑种草籽挥发油在大鼠多器官致癌生物测定中的癌症化学预防潜力
Oncol Lett. 2010 Sep;1(5):913-924. doi: 10.3892/ol_00000162. Epub 2010 Sep 1.
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Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia-reperfusion in rat skeletal muscle.黑种草子中所含的活性成分——百里醌对大鼠骨骼肌缺血再灌注损伤的影响。
Naunyn Schmiedebergs Arch Pharmacol. 2012 May;385(5):503-8. doi: 10.1007/s00210-012-0726-2. Epub 2012 Jan 22.
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