糖尿病发病率趋势：来自 2017 年全球疾病负担研究的结果及其对糖尿病预防的启示。
Trends in the incidence of diabetes mellitus: results from the Global Burden of Disease Study 2017 and implications for diabetes mellitus prevention.
机构信息
China-Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, PR China.
Department of Oral and Maxillofacial Surgery (Zhang Zhiyuan Academician Workstation), Hainan Western Central Hospital, Danzhou, 571700, China.
出版信息
BMC Public Health. 2020 Sep 17;20(1):1415. doi: 10.1186/s12889-020-09502-x.
BACKGROUD
Diabetes mellitus is a common chronic disease and a severe public health issue. The incidence trends for type 1 diabetes (TIDM) and type 2 diabetes (T2DM) have rarely been studied on a global scale. We aimed to determine the temporal and geographical trends of diabetes globally.
METHODS
Data on diabetes mellitus, including incidence, prevalence from 1990 to 2017 were obtained from the 2017 Global Burden of Disease study. We calculated the estimated annual percentage changes (EAPCs) in age-standardized incidence rate (ASIR) of diabetes mellitus according to sex, region, and disease type.
RESULTS
The worldwide incident cases of diabetes mellitus has increased by 102.9% from 11,303,084 cases in 1990 to 22,935,630 cases in 2017 worldwide, while the ASIR increased from 234 /100,000 persons (95% UI, 219-249) to 285/100,000 persons (95% UI, 262-310) in this period [EAPC = 0.87, 95% confidence interval (CI):0.79-0.96]. The global ASIRs of T1DM and T2DM both demonstrated significant increase during 1990-2017, with EAPCs of 0.34 (95% CI,0.30-0.39) and 0.89 (95% CI,0.80-0.97), respectively. The ASIR trends also varied considerably by regions and countries. The increase in ASIR was greatest in high sociodemographic index regions (EAPC = 1.05, 95% CI:0.92-1.17) and lowest in low-SDI regions (EAPC = 0.79, 95% CI:0.71-0.88).
CONCLUSIONS
Both the number of incident cases and ASIR of diabetes mellitus increased significantly during 1990-2017 worldwide, but the temporal trends varied markedly across regions and countries.
背景
糖尿病是一种常见的慢性疾病，也是严重的公共卫生问题。全球范围内，1 型糖尿病（T1DM）和 2 型糖尿病（T2DM）的发病趋势鲜有研究。本研究旨在确定全球范围内糖尿病的时间和地理趋势。
方法
我们从 2017 年全球疾病负担研究中获取了 1990 年至 2017 年糖尿病（包括发病率和患病率）的数据。我们按性别、地区和疾病类型计算了糖尿病年龄标准化发病率（ASIR）的估计年平均变化率（EAPC）。
结果
1990 年至 2017 年，全球糖尿病新发病例增加了 102.9%，从 11303084 例增至 22935630 例，同期 ASIR 从 234/100000 人（95%可信区间[95%CI]：219-249）增至 285/100000 人（95%CI：262-310）[EAPC=0.87，95%可信区间（95%CI）：0.79-0.96]。1990-2017 年，全球 T1DM 和 T2DM 的 ASIR 均呈显著上升趋势，EAPC 分别为 0.34（95%CI：0.30-0.39）和 0.89（95%CI：0.80-0.97）。ASIR 趋势在各地区和国家间差异较大。高社会人口指数地区的 ASIR 增幅最大（EAPC=1.05，95%CI：0.92-1.17），低社会人口指数地区的增幅最小（EAPC=0.79，95%CI：0.71-0.88）。
结论
1990-2017 年期间，全球糖尿病的发病人数和 ASIR 均显著增加，但各地区和国家间的时间趋势差异明显。
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