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与肠道脂肪消化和吸收相关的水相脂质阶段。

Aqueous lipid phases of relevance to intestinal fat digestion and absorption.

作者信息

Lindström M, Ljusberg-Wahren H, Larsson K, Borgström B

出版信息

Lipids. 1981 Oct;16(10):749-54. doi: 10.1007/BF02535343.

DOI:10.1007/BF02535343
PMID:7300594
Abstract

The phase behavior of monoglyceride/water systems, with oleic and linoleic acid as the dominating fatty acid residues, was investigated. Increased solubilization of triglycerides (oil) or oleic acid in the cubic liquid-crystalline phase formed by monoglyceride and water resulted in the formation of a reversed hexagonal liquid-crystalline phase followed by an L2-phase. The liquid-crystalline phases have different dispersion properties compared to each other in dilute micellar bile salt solutions. The cubic phase is found to be easily dispersed. The relevance of aqueous lipid phases other than micellar is discussed in relation to intestinal lipid digestion and absorption.

摘要

研究了以油酸和亚油酸作为主要脂肪酸残基的甘油单酯/水体系的相行为。甘油单酯和水形成的立方液晶相中甘油三酯(油)或油酸的增溶作用增强,导致形成反相六角液晶相,随后是L2相。在稀胶束胆盐溶液中,液晶相彼此具有不同的分散特性。发现立方相易于分散。讨论了除胶束相以外的水性脂质相在肠道脂质消化和吸收方面的相关性。

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2
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Partition of lipids between emulsified oil and micellar phases of glyceride-bile salt dispersions.甘油酯 - 胆盐分散体系中乳化油相和胶束相之间脂质的分配
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The absorption of triglyceride fat from the intestine.肠道对甘油三酯脂肪的吸收。
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THE INTRALUMINAL PHASE OF FAT DIGESTION IN MAN: THE LIPID CONTENT OF THE MICELLAR AND OIL PHASES OF INTESTINAL CONTENT OBTAINED DURING FAT DIGESTION AND ABSORPTION.人类脂肪消化的肠腔内阶段:脂肪消化与吸收过程中获得的肠内容物微胶粒相和油相的脂质含量。
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Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs.在达那唑的自乳化脂质基制剂中,相对于脂质增加表面活性剂(聚氧乙烯蓖麻油)的比例会降低比格犬的口服生物利用度。
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