SARS-CoV-2 非结构蛋白 6 触发内质网应激诱导的自噬以降解 STING1。
SARS-CoV-2 nonstructural protein 6 triggers endoplasmic reticulum stress-induced autophagy to degrade STING1.
机构信息
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
出版信息
Autophagy. 2023 Dec;19(12):3113-3131. doi: 10.1080/15548627.2023.2238579. Epub 2023 Jul 23.
aa: amino acid; ATF6: activating transcription factor 6; ATG5: autophagy related 5; CCPG1: cell cycle progression 1; CFTR: CF transmembrane conductance regulator; cGAMP: cyclic GMP-AMP; CGAS: cyclic GMP-AMP synthase; CHX: cycloheximide; Co-IP: co-immunoprecipitation; CQ: chloroquine; EIF2A/eIF2α: eukaryotic translation initiation factor 2A; EIF2AK3/PERK: eukaryotic translation initiation factor 2 alpha kinase 3; ER: endoplasmic reticulum; ERN1/IRE1: endoplasmic reticulum to nucleus signaling 1; GFP: green fluorescent protein; HSPA5/GRP78: heat shock protein family A (Hsp70) member 5; HSV-1: herpes simplex virus type 1; IFIT1: interferon induced protein with tetratricopeptide repeats 1; IFNB1/IFN-β: interferon beta 1; IRF3: interferon regulatory factor 3; ISG15: ISG15 ubiquitin like modifier; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MAP3K7/TAK1: mitogen-activated protein kinase kinase kinase 7; MAVS: mitochondrial antiviral signaling protein; MOI: multiplicity of infection; NFKB/NF-κB: nuclear factor kappa B; NSP6: non-structural protein 6; Δ106-108: deletion of amino acids 106-108 in NSP6 of SARS-CoV-2; Δ105-107: deletion of amino acids 105-107 in NSP6 of SARS-CoV-2; RETREG1/FAM134B: reticulophagy regulator 1; RIGI/DDX58: RNA sensor RIG-I; SQSTM1/p62: sequestosome 1; STING1: stimulator of interferon response cGAMP interactor 1; TBK1: TANK binding kinase 1.
aa：氨基酸；ATF6：激活转录因子 6；ATG5：自噬相关 5；CCPG1：细胞周期进展 1；CFTR：CF 跨膜电导调节剂；cGAMP：环鸟苷酸-AMP；CGAS：环鸟苷酸-AMP 合酶；CHX：环己酰亚胺；Co-IP：免疫共沉淀；CQ：氯喹；EIF2A/eIF2α：真核翻译起始因子 2A；EIF2AK3/PERK：真核翻译起始因子 2α激酶 3；ER：内质网；ERN1/IRE1：内质网到细胞核信号 1；GFP：绿色荧光蛋白；HSPA5/GRP78：热休克蛋白家族 A（Hsp70）成员 5；HSV-1：单纯疱疹病毒 1；IFIT1：干扰素诱导的四肽重复蛋白 1；IFNB1/IFN-β：β 干扰素 1；IRF3：干扰素调节因子 3；ISG15：ISG15 泛素样修饰物；MAP1LC3B/LC3B：微管相关蛋白 1 轻链 3β；MAP3K7/TAK1：丝裂原活化蛋白激酶激酶激酶 7；MAVS：线粒体抗病毒信号蛋白；MOI：感染复数；NFKB/NF-κB：核因子 kappa B；NSP6：非结构蛋白 6；Δ106-108：SARS-CoV-2 NSP6 中氨基酸 106-108 的缺失；Δ105-107：SARS-CoV-2 NSP6 中氨基酸 105-107 的缺失；RETREG1/FAM134B：自噬调节因子 1；RIGI/DDX58：RNA 传感器 RIG-I；SQSTM1/p62：自噬体 1；STING1：干扰素反应 cGAMP 相互作用蛋白 1 的刺激物；TBK1：TANK 结合激酶 1。
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