Fortrea, Inc., Durham, NC, United States.
Labcorp Drug Development Inc., Princeton, NJ, United States.
Front Immunol. 2023 Jul 7;14:1208137. doi: 10.3389/fimmu.2023.1208137. eCollection 2023.
As the first responders, neutrophils lead the innate immune response to infectious pathogens and inflammation inducing agents. The well-established pathogen neutralizing strategies employed by neutrophils are phagocytosis, the action of microbicide granules, the production of ROS, and the secretion of neutrophil extracellular traps (NETs). Only recently, the ability of neutrophils to sense and respond to pathogen-associated molecular patterns is being appreciated. This review brings together the current information about the intracellular recognition of DNA by neutrophils and proposes models of signal amplification in immune response. Finally, the clinical relevance of DNA sensing by neutrophils in infectious and non-infectious diseases including malignancy are also discussed.
作为第一反应者，中性粒细胞主导着对感染病原体和炎症诱导剂的先天免疫反应。中性粒细胞采用的成熟的病原体中和策略包括吞噬作用、微生物杀伤颗粒的作用、ROS 的产生以及中性粒细胞胞外陷阱（NETs）的分泌。直到最近，人们才开始意识到中性粒细胞感知和应对病原体相关分子模式的能力。这篇综述汇集了目前关于中性粒细胞识别 DNA 的细胞内信息，并提出了免疫反应中信号放大的模型。最后，还讨论了中性粒细胞在感染性和非感染性疾病（包括恶性肿瘤）中对 DNA 的感知的临床相关性。
