Smith Shelby J, Wrobel Julia, Brooks-Russell Ashley, Kosnett Michael J, Sammel Mary D
Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Injury and Violence Prevention Center, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Cannabis. 2023 Jul 5;6(2):123-132. doi: 10.26828/cannabis/2023/000156. eCollection 2023.
This paper evaluated a novel, tablet-based neurocognitive and psychomotor test battery for detecting impairment from acute cannabis smoking using advanced quantitative methods. The study was conducted in a state with legal, recreational cannabis use and included participants who use cannabis occasionally or daily, and a no use comparison group.
Participants completed a tablet-based test assessing reaction time, decision making, working memory and spatial-motor performance. The test was completed before and after participants smoked cannabis (or after a rest period in the case of controls). An Exploratory Factor Analysis approach was implemented to reduce dimensionality and evaluate correlations across the four assessed domains. Linear regression models were utilized to quantify associations between factor scores and cannabis use groups (daily vs. occasional vs. no use).
Seven factors were identified explaining 56.7% of the variance among the 18 measures. Regression models of the change in factors after cannabis smoking indicated those who use cannabis daily demonstrated poorer performance on a latent factor termed (standardized coefficient 0.567, 95% CI: 0.178, 0.955; = 0.005) compared to those with no use. Those who use cannabis occasionally exhibited a decline in performance on a latent factor termed (standardized coefficient 0.714, 95% CI: 0.092, 1.336; = 0.025) compared to no use.
This analysis demonstrates an innovative, quantitative approach to study how cannabis consumption affects neurocognitive and psychomotor performance. Results demonstrated that acute cannabis use is associated with changes in neurocognitive and psychomotor performance, with differences based on the pattern of occasional or daily use.
本文使用先进的定量方法评估了一种基于平板电脑的新型神经认知和心理运动测试组合，用于检测急性吸食大麻造成的损伤。该研究在一个大麻用于娱乐合法化的州进行，纳入了偶尔或每日使用大麻的参与者以及不使用大麻的对照组。
参与者完成一项基于平板电脑的测试，评估反应时间、决策能力、工作记忆和空间运动表现。该测试在参与者吸食大麻之前和之后（对于对照组则是在休息期之后）完成。采用探索性因素分析方法来降低维度并评估四个评估领域之间的相关性。利用线性回归模型量化因素得分与大麻使用组（每日使用与偶尔使用与不使用）之间的关联。
识别出七个因素，解释了18项测量指标中56.7%的方差。大麻吸食后因素变化的回归模型表明，与不使用大麻者相比，每日使用大麻者在一个称为“ ”的潜在因素上表现较差（标准化系数0.567，95%置信区间：0.178，0.955；P = 0.005）。与不使用大麻者相比，偶尔使用大麻者在一个称为“ ”的潜在因素上表现下降（标准化系数0.714，95%置信区间：0.092，1.336；P = 0.025）。
该分析展示了一种创新的定量方法，用于研究大麻消费如何影响神经认知和心理运动表现。结果表明，急性大麻使用与神经认知和心理运动表现的变化相关，且根据偶尔或每日使用模式存在差异。
