Calazans Neto João Vicente, Reis Andréa Cândido Dos, Valente Mariana Lima da Costa
Department of Dental Materials and Prosthodontics, Ribeirão Preto Dental School, University of São Paulo (USP), Ribeirão Preto, Brazil.
Heliyon. 2023 Jun 10;9(6):e17105. doi: 10.1016/j.heliyon.2023.e17105. eCollection 2023 Jun.
The objective of the systematic review is to find an answer to a question: "Do surface treatments on titanium implants produced by additive manufacturing improve osseointegration, compared to untreated surfaces?". This review followed the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA 2020) and was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42022321351). Searches were performed in PubMed, Scopus, Science Direct, Embase, and Google Scholar databases on March 22nd, 2022. Articles were chosen in 2 steps by 2 blinded reviewers based on previously selected inclusion criteria: articles in animals that addressed the influence of surface treatments on osseointegration in implants produced by additive manufacturing. Articles were excluded that (1) did not use titanium surface, 2) that did not evaluate surface treatments, 3) that did not described osseointegration, 4) Studies with only in vitro analyses, clinical studies, systematic reviews, book chapters, short communications, conference abstracts, case reports and personal opinions.). 1003 articles were found and, after applying the eligibility criteria, 17 were used for the construction of this review. All included studies found positive osseointegration results from performing surface treatments on titanium. The risk of bias was analyzed using the SYRCLE assessment tool. Surface treatments are proposed to promote changes in the microstructure and composition of the implant surface to favor the adhesion of bone cells responsible for osseointegration. It is observed that despite the benefits generated by the additive manufacturing process in the microstructure of the implant surface, surface treatments are still indispensable, as they can promote more suitable characteristics for bone-implant integration. It can be concluded that the surface treatments evaluated in this systematic review, performed on implants produced by additive manufacturing, optimize osseointegration, as it allows the creation of a micro-nano-textured structure that makes the surface more hydrophilic and allows better contact bone-implant.
“与未处理的表面相比，增材制造生产的钛植入物的表面处理是否能改善骨整合？”。本评价遵循系统评价和Meta分析的首选报告项目（PRISMA 2020），并在国际系统评价前瞻性注册库（PROSPERO）中注册（CRD42022321351）。于2022年3月22日在PubMed、Scopus、Science Direct、Embase和谷歌学术数据库中进行了检索。由2名盲法评审员根据先前选定的纳入标准分两步选择文章：涉及动物研究中表面处理对增材制造生产的植入物骨整合影响的文章。排除以下文章：（1）未使用钛表面的文章；（2）未评估表面处理的文章；（3）未描述骨整合的文章；（4）仅进行体外分析的研究、临床研究、系统评价、书籍章节、简短通讯、会议摘要、病例报告和个人观点。共检索到1003篇文章，应用纳入标准后，17篇用于本评价的构建。所有纳入研究均发现对钛进行表面处理可获得积极的骨整合结果。使用SYRCLE评估工具分析了偏倚风险。表面处理旨在促进植入物表面微观结构和成分的变化，以利于负责骨整合的骨细胞的黏附。可以观察到，尽管增材制造工艺在植入物表面微观结构方面带来了益处，但表面处理仍然不可或缺，因为它们可以促进更适合骨-植入物整合的特性。可以得出结论，本系统评价中评估的对增材制造生产的植入物进行的表面处理可优化骨整合，因为它允许创建微纳纹理结构，使表面更具亲水性，并允许更好的骨-植入物接触。
