Shaaban Sanaa, Al-Beltagi Mohammed, El Rashidy Omnia, Nassar May, El Gendy Yasmin
Children's Hospital, Faculty of Medicine, Ain Shams University, Abbassia, Egypt.
Paediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Front Pediatr. 2023 Jul 6;11:1221781. doi: 10.3389/fped.2023.1221781. eCollection 2023.
Dietary therapies play a crucial role in managing patients, especially those who have specific types of epilepsy, display adverse effects, or are not responding to pharmacological treatments. The ketogenic diet (KD) is a high-fat, restricted carbohydrate, and adequate protein regimen. The KD has proven to be an effective nonpharmacological treatment for drug-resistant epilepsy (DRE) by generating ketones that act as an alternative fuel source for the brain, thereby reducing the occurrence of seizures. The advantages of KD have been attributed to its universal availability, numerous administration techniques, and affordability.
This article presents the KD algorithm developed by a multidisciplinary team of experts at the Children's Hospital, Ain Shams University, Egypt. The algorithm serves as a guide for implementing the KD in the treatment of DRE in children. The algorithm has been previously validated through a study.
The algorithm consists of seven essential stages: (1) referral of patients to the Complex Epilepsy Committee, (2) pre-diet assessment of patients, (3) referral of patients to the Clinical Nutrition (CN) team, (4) diet selection and initiation, (5) seizure follow-up and diet fine-tuning, (6) diet reassessment after 3 months, and (7) evaluation of the KD journey after 24 months.
The KD algorithm was systematically developed and proved highly influential in facilitating the implementation of the KD. The algorithm yielded significant health benefits in pediatric patients.
The KD algorithm provides a systematic approach to implementing the ketogenic diet and has demonstrated positive health outcomes in pediatric patients.
饮食疗法在治疗患者方面发挥着关键作用，尤其是对于患有特定类型癫痫、出现不良反应或对药物治疗无反应的患者。生酮饮食（KD）是一种高脂肪、碳水化合物受限且蛋白质充足的饮食方案。事实证明，KD通过产生酮体作为大脑的替代燃料来源，从而减少癫痫发作的发生，是一种有效的耐药性癫痫（DRE）非药物治疗方法。KD的优势在于其普遍可得性、多种给药技术以及可承受性。
本文介绍了埃及艾因夏姆斯大学儿童医院多学科专家团队开发的KD算法。该算法可作为在儿童DRE治疗中实施KD的指南。该算法此前已通过一项研究得到验证。
该算法包括七个基本阶段：（1）将患者转诊至复杂癫痫委员会；（2）对患者进行饮食前评估；（3）将患者转诊至临床营养（CN）团队；（4）饮食选择与开始；（5）癫痫发作随访与饮食微调；（6）3个月后进行饮食重新评估；（7）24个月后评估KD治疗过程。
KD算法是经过系统开发的，并且在促进KD的实施方面被证明具有高度影响力。该算法在儿科患者中产生了显著的健康益处。
KD算法为实施生酮饮食提供了一种系统方法，并已在儿科患者中显示出积极的健康结果。
