Saito Takashi, Mizumoto Masashi, Oshiro Yoshiko, Miyamoto Toshio, Kamizawa Satoshi, Nakamura Masatoshi, Ishida Toshiki, Makishima Hirokazu, Numajiri Haruko, Nakai Kei, Sakae Takeji, Sakurai Hideyuki
Department of Radiation Oncology, University of Tsukuba, Tsukuba, Japan.
Department of Radiation Oncology, Tsukuba Medical Center Hospital, Tsukuba, Japan.
Tech Innov Patient Support Radiat Oncol. 2023 Jul 7;27:100218. doi: 10.1016/j.tipsro.2023.100218. eCollection 2023 Sep.
The correlation between sensory light flash and proton beam delivery was evaluated by measuring the timing of pulse beam delivery and light flash sensing using an event recorder in an 83-year-old patient receiving proton beam therapy (PBT) for nasopharyngeal adenoid cystic carcinoma. The treatment dose was 65 Gy (RBE) in 26 fractions with 2 ports, and both beams included the visual pathway (retina, optic nerve, chiasma). Measurements were obtained in 13 of the 26 fractions. The patient sensed a light flash in all 13 fractions and pressed the recorder button for 426 of the 430 pulsed beam deliveries, giving a sensing rate of 99.1%. The median duration of button-pressing of 0.3 s was almost the same as that of the beam pulse of 0.2 s, with a reaction time lag of 0.35 s. These results suggest a consistency between light flash during PBT and the timing of irradiation.
在一名接受质子束治疗（PBT）的83岁鼻咽癌腺样囊性癌患者中，通过使用事件记录器测量脉冲束输送和闪光感知的时间，评估了感觉性闪光与质子束输送之间的相关性。治疗剂量为65 Gy（相对生物效应），分26次给予，通过2个射野，两束射线均包括视觉通路（视网膜、视神经、视交叉）。在26次照射中的13次进行了测量。患者在所有13次照射中均感觉到闪光，并在430次脉冲束输送中的426次按下了记录器按钮，感知率为99.1%。按钮按下的中位持续时间为0.3秒，与0.2秒的束脉冲几乎相同，反应时间滞后0.35秒。这些结果表明PBT期间的闪光与照射时间之间具有一致性。
