Oshiro Yoshiko, Mizumoto Masashi, Miyamoto Toshio, Sumiya Taisuke, Fujioka Den, Shirataki Haruka, Nakamura Masatoshi, Ishida Toshiki, Iizumi Takashi, Saito Takashi, Numajiri Haruko, Makishima Hirokazu, Nakai Kei, Maruo Kazushi, Sakae Takeji, Sakurai Hideyuki
Department of Radiation Oncology, Tsukuba Medical Center Hospital, Tsukuba, JPN.
Department of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, JPN.
Cureus. 2023 Sep 6;15(9):e44790. doi: 10.7759/cureus.44790. eCollection 2023 Sep.
Background Abnormal sensations were frequently experienced by patients who received irradiation of the brain or head and neck region. We have previously suggested correlations with irradiation of the nasal cavity and retina. Purpose We performed a retrospective dose-volume histogram analysis focused on the brain and head and neck tumor to examine the relationship between these abnormal sensations and the details of irradiation. Methods Multivariate logistic regression models were applied for the presence or absence of light flash and odor. Gender, age, radiotherapy method (proton beam therapy vs. photon radiotherapy), dose of retina, optic nerve, chiasmatic gland, pituitary, nasal cavity, oral cavity, frontal lobe, parietal lobe, occipital lobe, temporal lobe, amygdala, and hippocampus were set as candidates of explanatory variables. Results Light flash and odor during radiotherapy have been suggested to be associated with younger age and retina and nasal cavity irradiation. Multivariate analyses including dose-volume histograms indicated that light flash was related to age, chiasmatic gland irradiation, and pituitary dose, and odor was related to age and nasal cavity irradiation. Conclusion Our results indicate that light flash during radiotherapy is caused by irradiation of the visual pathway and that odor is caused by irradiation of the nasal cavity or olfactory bulb.
背景 接受脑部或头颈部区域放疗的患者经常会出现异常感觉。我们之前曾提出这些异常感觉与鼻腔和视网膜的放疗有关。目的 我们进行了一项回顾性剂量体积直方图分析，重点关注脑和头颈部肿瘤，以研究这些异常感觉与放疗细节之间的关系。方法 对是否出现闪光和气味应用多因素逻辑回归模型。将性别、年龄、放疗方法（质子束治疗与光子放疗）、视网膜、视神经、视交叉、垂体、鼻腔、口腔、额叶、顶叶、枕叶、颞叶、杏仁核和海马体的剂量设定为解释变量的候选因素。结果 放疗期间的闪光和气味被认为与年龄较小以及视网膜和鼻腔放疗有关。包括剂量体积直方图的多因素分析表明，闪光与年龄、视交叉放疗和垂体剂量有关，气味与年龄和鼻腔放疗有关。结论 我们的结果表明，放疗期间的闪光是由视觉通路的照射引起的，而气味是由鼻腔或嗅球的照射引起的。
