Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore.
Experimental Fetal Medicine Group, Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore.
Stem Cells Transl Med. 2023 Aug 16;12(8):510-526. doi: 10.1093/stcltm/szad041.
Neurodegenerative diseases (ND) are an entire spectrum of clinical conditions that affect the central and peripheral nervous system. There is no cure currently, with treatment focusing mainly on slowing down progression or symptomatic relief. Cellular therapies with various cell types from different sources are being conducted as clinical trials for several ND diseases. They include neural, mesenchymal and hemopoietic stem cells, and neural cells derived from embryonic stem cells and induced pluripotent stem cells. In this review, we present the list of cellular therapies for ND comprising 33 trials that used neural stem progenitors, 8 that used differentiated neural cells ,and 109 trials that involved non-neural cells in the 7 ND. Encouraging results have been shown in a few early-phase clinical trials that require further investigations in a randomized setting. However, such definitive trials may not be possible given the relative cost of the trials, and in the setting of rare diseases.
神经退行性疾病（ND）是一组影响中枢和周围神经系统的临床病症。目前尚无治愈方法，治疗主要集中在减缓疾病进展或缓解症状。目前正在进行各种来源的不同细胞类型的细胞疗法临床试验，用于多种 ND 疾病。这些细胞包括神经细胞、间充质细胞和造血干细胞，以及源自胚胎干细胞和诱导多能干细胞的神经细胞。在这篇综述中，我们列出了用于 ND 的细胞疗法清单，其中包括 33 项使用神经干细胞前体细胞的试验、8 项使用分化神经细胞的试验，以及 7 种 ND 中涉及非神经细胞的 109 项试验。少数早期临床试验显示出了令人鼓舞的结果，这些试验需要在随机对照的条件下进一步研究。然而，鉴于试验的相对成本，以及在罕见疾病的情况下，这种明确的试验可能是不可能的。
