无淋巴结转移的涎腺腺样囊性癌患者的预后评分。
Prognostic scores for patients with salivary adenoid cystic carcinoma without lymph node metastasis.
机构信息
Department of Otolaryngology‑Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan; Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Department of Otolaryngology‑Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
出版信息
Oral Oncol. 2023 Oct;145:106491. doi: 10.1016/j.oraloncology.2023.106491. Epub 2023 Jul 22.
Adenoid cystic carcinoma (AdCC) of salivary gland grows relatively slowly, but occasionally develops distant metastasis. Although cervical lymph node metastasis (LNM) has been reported as a strong prognostic factor, most of AdCC do not have LNM. In this study, we investigated the prognostic factors to predict disease free survival (DFS), distant metastasis free survival (DMFS), and overall survival (OS) for 175 patients surgically treated for AdCC without LNM, and developed prognostic score (PS) determined as number of positive prognostic factors. The following emerged as significant prognostic factors: positive surgical margin in DFS, pT3/4 and positive surgical margin in DMFS, and positive surgical margin and high-histological grade in OS. 10-year DFS rates were 56.4% in PS0, and 19.1% in PS1 (p < 0.0001). 10-year DMFS rates were 86.3% in PS0, 56.4% in PS1, and 30.7% in PS2 (p < 0.0001). 10-year OS rates were 100% in PS0, 73.3% in PS1, and 38.8% in PS2 (p < 0.0001).
涎腺腺样囊性癌（AdCC）生长相对缓慢，但偶尔会发生远处转移。虽然颈部淋巴结转移（LNM）已被认为是一个强烈的预后因素，但大多数 AdCC 没有 LNM。在这项研究中，我们研究了无 LNM 的 AdCC 患者的手术治疗的无病生存（DFS）、无远处转移生存（DMFS）和总生存（OS）的预后因素，并开发了预测预后的评分（PS），由阳性预后因素的数量决定。DFS 的显著预后因素包括：手术切缘阳性、pT3/4 和手术切缘阳性；DMFS 的显著预后因素包括：手术切缘阳性和高组织学分级；OS 的显著预后因素包括：手术切缘阳性和高组织学分级。PS0 的 10 年 DFS 率为 56.4%，PS1 为 19.1%（p<0.0001）。PS0 的 10 年 DMFS 率为 86.3%，PS1 为 56.4%，PS2 为 30.7%（p<0.0001）。PS0 的 10 年 OS 率为 100%，PS1 为 73.3%，PS2 为 38.8%（p<0.0001）。
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