Cellular, and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 19195-4763, Iran.
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 19395-4741, Iran.
Sci Rep. 2023 Jul 24;13(1):11934. doi: 10.1038/s41598-023-38326-z.
We sought to investigate the familial aggregation and family-based heritability of dietary intakes among adults in a population-based longitudinal study of the Tehran Lipid and Glucose Study (TLSG). Total of 4359 males and 5439 females entered our study. We categorized foods into main groups based on the literature on main food groups and their subgroups among the Iranian dietary habits and food culture as follows: grains, fruits, vegetables, dairy, meats, legume, nuts, beverages, snacks, and fats. The intraclass correlation coefficients (ICC) are estimated to verify familial resemblance of dietary habits for all relative pairs and spouses. Family-based heritability is obtained using a mixed effect framework with likelihood-based approach. For almost all food groups, the correlation between parents and offsprings tended to be larger than those of siblings. Family-based heritability of food groups varies from the lowest 6.36% for snacks to the highest 25.67% for fruits, and 25.66% for legume. Our findings indicated weak-to-moderate similarities between parents' and offspring's food intakes; however, the similarity in parent-child food intakes was different, and the correlation in mother-daughter food intakes was stronger than other parent-child correlations, and almost all of dietary components showed strong family-based heritability.
我们旨在研究德黑兰血脂和血糖研究（TLSG）中人群为基础的纵向研究中成年人饮食摄入的家族聚集和基于家庭的遗传性。共有 4359 名男性和 5439 名女性参与了我们的研究。我们根据伊朗饮食习俗和饮食文化中的主要食物组及其亚组的文献，将食物分为主要组：谷物、水果、蔬菜、乳制品、肉类、豆类、坚果、饮料、零食和脂肪。采用混合效应框架和基于似然的方法获得了基于家庭的遗传率。对于几乎所有的食物组，父母和子女之间的相关性往往大于兄弟姐妹之间的相关性。食物组的基于家庭的遗传性从最低的 6.36%（零食）到最高的 25.67%（水果）和 25.66%（豆类）不等。我们的研究结果表明，父母和子女的食物摄入量之间存在弱到中度的相似性；然而，父母与子女之间的食物摄入量的相似性是不同的，母亲与女儿之间的食物摄入量的相关性强于其他父母与子女的相关性，并且几乎所有的饮食成分都表现出很强的基于家庭的遗传性。
