Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Curr Med Chem. 2024;31(24):3715-3732. doi: 10.2174/0929867331666230721154653.
Gouty arthritis is a complex form of inflammatory arthritis, triggered by the sedimentation of monosodium urate crystals in periarticular tissues, synovial joints, and other sites in the body. Curcumin is a natural polyphenol compound, isolated from the rhizome of the plant , possessing countless physiological features, including antioxidant, anti-inflammatory, and anti-rheumatic qualities.
This study aimed to discuss the beneficial impacts of curcumin and its mechanism in treating gout disease.
Ten English and Persian databases were used to conduct a thorough literature search. Studies examining the anti-gouty arthritis effects of curcumin and meeting the inclusion criteria were included.
According to the studies, curcumin has shown xanthine oxidase and urate transporter- 1 inhibitory properties, uric acid inhibitory characteristics, and antioxidant and anti- inflammatory effects. However, some articles found no prominent reduction in uric acid levels.
In this review, we emphasized the potency of curcumin and its compounds against gouty arthritis. Despite the potency, we suggest an additional well-designed evaluation of curcumin, before its therapeutic effectiveness is completely approved as an antigouty arthritis agent.
痛风性关节炎是一种复杂的炎症性关节炎，由单钠尿酸盐晶体在关节周围组织、滑膜关节和身体其他部位的沉积引发。姜黄素是一种天然多酚化合物，从植物根茎中分离出来，具有无数的生理特性，包括抗氧化、抗炎和抗风湿特性。
本研究旨在探讨姜黄素及其治疗痛风病的机制的有益影响。
使用 10 个英文和波斯文数据库进行全面的文献检索。纳入研究姜黄素抗痛风性关节炎作用并符合纳入标准的研究。
根据这些研究，姜黄素具有黄嘌呤氧化酶和尿酸转运蛋白-1抑制特性、尿酸抑制特性、抗氧化和抗炎作用。然而，一些文章发现尿酸水平没有明显降低。
在本综述中，我们强调了姜黄素及其化合物对痛风性关节炎的功效。尽管有这种功效，但我们建议在完全批准姜黄素作为抗痛风关节炎药物之前，对其进行额外的精心设计的评估。
