Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Curr Med Chem. 2023;30(20):2312-2339. doi: 10.2174/0929867329666220817125800.
Organophosphate compounds are regarded as a class of pesticides that are used in farming. Their extensive use, especially in developing countries, is a serious public health problem. Numerous studies have shown the effects of these toxins on various parts of the human and other vertebrates' bodies, including the cardiovascular, hepatobiliary, renal, and reproductive systems. Curcumin is a polyphenol compound obtained from the rhizome of the Curcuma longa. Curcumin has been known as a dietary spice, food additive, and traditional medicine since many years ago. In recent decades, the medicinal characteristics, clinical aspects, and biological activity of curcumin have been extensively examined. The most examined positive characteristics of curcumin are its anti- inflammatory and anti-oxidant qualities. This review will deal with the pharmacological properties of curcumin as well as an update of currently available studies in terms of curcumin's uses and function against organophosphate pesticides-induced toxicity on different human organs.
有机磷化合物被认为是一类用于农业的农药。它们的广泛使用，尤其是在发展中国家，是一个严重的公共卫生问题。许多研究表明，这些毒素对人体和其他脊椎动物的各个部位都有影响，包括心血管、肝胆、肾脏和生殖系统。姜黄素是一种从姜黄根茎中提取的多酚化合物。多年来，姜黄素一直被认为是一种膳食香料、食品添加剂和传统药物。近几十年来，姜黄素的药用特性、临床方面和生物活性得到了广泛的研究。姜黄素最被研究的积极特性是其抗炎和抗氧化特性。这篇综述将讨论姜黄素的药理学特性，并更新目前关于姜黄素在不同人体器官中对抗有机磷农药诱导的毒性的用途和功能的研究。
