文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

评估与粪便微生物组和宏蛋白质组相关的婴儿牛乳过敏的生长情况。

Assessment of infant outgrowth of cow's milk allergy in relation to the faecal microbiome and metaproteome.

机构信息

Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands.

Department of Food Science and Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.

出版信息

Sci Rep. 2023 Jul 25;13(1):12029. doi: 10.1038/s41598-023-39260-w.

DOI:10.1038/s41598-023-39260-w
PMID:37491408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10368738/
Abstract

Previous studies provide evidence for an association between modifications of the gut microbiota in early life and the development of food allergies. We studied the faecal microbiota composition (16S rRNA gene amplicon sequencing) and faecal microbiome functionality (metaproteomics) in a cohort of 40 infants diagnosed with cow's milk allergy (CMA) when entering the study. Some of the infants showed outgrowth of CMA after 12 months, while others did not. Faecal microbiota composition of infants was analysed directly after CMA diagnosis (baseline) as well as 6 and 12 months after entering the study. The aim was to gain insight on gut microbiome parameters in relation to outgrowth of CMA. The results of this study show that microbiome differences related to outgrowth of CMA can be mainly identified at the taxonomic level of the 16S rRNA gene, and to a lesser extent at the protein-based microbial taxonomy and functional protein level. At the 16S rRNA gene level outgrowth of CMA is characterized by lower relative abundance of Lachnospiraceae at baseline and lower Bacteroidaceae at visit 12 months.

摘要

先前的研究为生命早期肠道微生物群的改变与食物过敏的发展之间的关联提供了证据。我们研究了 40 名被诊断患有牛奶过敏（CMA）的婴儿的粪便微生物群组成（16S rRNA 基因扩增子测序）和粪便微生物组功能（宏蛋白质组学）。一些婴儿在进入研究 12 个月后出现 CMA 增长，而另一些则没有。在 CMA 诊断后（基线）以及进入研究后 6 个月和 12 个月直接分析了婴儿的粪便微生物群组成。目的是了解与 CMA 增长相关的肠道微生物组参数。本研究的结果表明，与 CMA 增长相关的微生物组差异主要可以在 16S rRNA 基因的分类学水平上识别，在基于蛋白质的微生物分类和功能蛋白质水平上则较少。在 16S rRNA 基因水平上，CMA 的增长特征是基线时lachnospiraceae 的相对丰度较低，12 个月时 visit 时 bacteroidaceae 的相对丰度较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/09bbb1877169/41598_2023_39260_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/1345513843ed/41598_2023_39260_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/0f7db872f14d/41598_2023_39260_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/bbfee44f9c93/41598_2023_39260_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/d6ea5e4826fe/41598_2023_39260_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/b32c4ed81693/41598_2023_39260_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/7bf9b0c41c36/41598_2023_39260_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/09bbb1877169/41598_2023_39260_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/1345513843ed/41598_2023_39260_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/0f7db872f14d/41598_2023_39260_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/bbfee44f9c93/41598_2023_39260_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/d6ea5e4826fe/41598_2023_39260_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/b32c4ed81693/41598_2023_39260_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/7bf9b0c41c36/41598_2023_39260_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03c6/10368738/09bbb1877169/41598_2023_39260_Fig7_HTML.jpg

相似文献

[1]
Assessment of infant outgrowth of cow's milk allergy in relation to the faecal microbiome and metaproteome.

Sci Rep. 2023-7-25

[2]
Specific Gut Microbiome Signatures in Children with Cow's Milk Allergy.

Nutrients. 2024-8-18

[3]
Early-life gut microbiome composition and milk allergy resolution.

J Allergy Clin Immunol. 2016-10

[4]
Rectal bleeding in infancy: clinical, allergological, and microbiological examination.

Pediatrics. 2006-4

[5]
Influences of non-IgE-mediated cow's milk protein allergy-associated gut microbial dysbiosis on regulatory T cell-mediated intestinal immune tolerance and homeostasis.

Microb Pathog. 2021-9

[6]
Early-life gut microbiome and cow's milk allergy- a prospective case - control 6-month follow-up study.

Saudi J Biol Sci. 2018-7

[7]
Further Insights into the Gut Microbiota of Cow's Milk Allergic Infants: Analysis of Microbial Functionality and Its Correlation with Three Fecal Biomarkers.

Int J Mol Sci. 2023-5-25

[8]
Gut Microbiota Profile in Children with IgE-Mediated Cow's Milk Allergy and Cow's Milk Sensitization and Probiotic Intestinal Persistence Evaluation.

Int J Mol Sci. 2021-2-6

[9]
Amoxicillin does not affect the development of cow's milk allergy in a Brown Norway rat model.

Scand J Immunol. 2022-5

[10]
Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow's milk allergy.

Sci Rep. 2018-8-21

引用本文的文献

[1]
Gut Microbiota Differences in Infants with Cow-Milk-Induced Allergic Proctocolitis: A Comparative Cross-Sectional Study.

Children (Basel). 2025-6-5

[2]
The impact of gestational diabetes mellitus on maternal-fetal pregnancy outcomes and fetal growth: a multicenter longitudinal cohort study.

Front Pediatr. 2025-5-20

[3]
A multi-omics machine learning classifier for outgrowth of cow's milk allergy in children.

Mol Omics. 2025-5-23

[4]
Exploring the Fecal Metabolome in Infants With Cow's Milk Allergy: The Distinct Impacts of Cow's Milk Protein Tolerance Acquisition and of Synbiotic Supplementation.

Mol Nutr Food Res. 2025-1

[5]
Immunoglobulin-coating patterns reveal altered humoral responses to gut bacteria in pediatric cow milk allergies.

J Transl Med. 2024-11-12

[6]
The Association between Gut Microbiota and Serum Biomarkers in Children with Atopic Dermatitis.

Biomedicines. 2024-10-15

[7]
Gut microbiome features in pediatric food allergy: a scoping review.

Front Allergy. 2024-9-25

[8]
Evolutive Study of Dietary Aspects and Intestinal Microbiota of Pediatric Cohort with Cow's Milk Protein Allergy.

Children (Basel). 2024-9-12

[9]
Specific Gut Microbiome Signatures in Children with Cow's Milk Allergy.

Nutrients. 2024-8-18

[10]
Probiotics in the New Era of Human Milk Oligosaccharides (HMOs): HMO Utilization and Beneficial Effects of subsp. M-63 on Infant Health.

Microorganisms. 2024-5-17

本文引用的文献

[1]
Specific gut microbiome signatures and the associated pro-inflamatory functions are linked to pediatric allergy and acquisition of immune tolerance.

Nat Commun. 2021-10-13

[2]
Tolerance development in cow's milk-allergic infants receiving amino acid-based formula: A randomized controlled trial.

J Allergy Clin Immunol. 2022-2

[3]
UniProt: the universal protein knowledgebase in 2021.

Nucleic Acids Res. 2021-1-8

[4]
Analysis of the infant gut microbiome reveals metabolic functional roles associated with healthy infants and infants with atopic dermatitis using metaproteomics.

PeerJ. 2020-9-25

[5]
Evolution of the Gut Microbiome in Early Childhood: A Cross-Sectional Study of Chinese Children.

Front Microbiol. 2020-4-3

[6]
The Relationship between the Infant Gut Microbiota and Allergy. The Role of and Prebiotic Oligosaccharides in the Activation of Anti-Allergic Mechanisms in Early Life.

Nutrients. 2020-3-29

[7]
Validation of the Patient-Oriented SCORing for Atopic Dermatitis tool for black skin.

J Eur Acad Dermatol Venereol. 2020-4

[8]
A synbiotic concept containing spore-forming strains and a prebiotic fiber blend consistently enhanced metabolic activity by modulation of the gut microbiome .

Int J Pharm X. 2019-7-6

[9]
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2.

Nat Biotechnol. 2019-8

[10]
Immediate vs delayed cow's milk protein allergy in terms of tolerance at year 1.

Ann Allergy Asthma Immunol. 2019-9

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索