Liu Yu, Ma Jingmei, Zhu Baoli, Liu Fei, Qin Shengtang, Lv Na, Feng Ye, Wang Shuxian, Yang Huixia
Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Beijing, China.
Front Microbiol. 2023 Jul 10;14:1163269. doi: 10.3389/fmicb.2023.1163269. eCollection 2023.
The establishment of human gut microbiota in early life is closely associated with both short- and long-term infant health. Delivery mode and feeding pattern are two important determinants of infant gut microbiota. In this longitudinal cohort study, we examined the interplay between the delivery mode and feeding pattern on the dynamics of infant gut microbiota from 6 weeks to 6 months post-delivery in 139 infants. We also assessed the relationship between infant respiratory infection susceptibility and gut microbial changes associated with delivery mode and feeding pattern. At 6 weeks postpartum, the composition and structure of gut microbiota of cesarean section-delivered (CSD) infants differed from those of vaginally delivered (VD) infants, with decreased and and increased , and . At 6 months postpartum, these delivery mode-induced microbial shifts were restored by exclusive breastfeeding, resulting in similar gut microbial profiles between VD and CSD infants who were exclusively breastfed ( = 0.57) and more variable gut microbial profiles between VD and CSD infants who were mixed fed ( < 0.001). We identified that the VD-associated genera were enriched in healthy infants, while the CSD-associated genera were enriched in infants who suffered from respiratory infections. Our findings indicate that exclusive breastfeeding may play a health-promoting role by reducing infant respiratory infection susceptibility through the restoration of gut microbiota perturbations caused by cesarean section.
生命早期人类肠道微生物群的建立与婴儿的短期和长期健康密切相关。分娩方式和喂养模式是婴儿肠道微生物群的两个重要决定因素。在这项纵向队列研究中，我们调查了139名婴儿出生后6周龄至6月龄期间，分娩方式和喂养模式对婴儿肠道微生物群动态变化的相互作用。我们还评估了婴儿呼吸道感染易感性与因分娩方式和喂养模式导致的肠道微生物变化之间的关系。产后6周时，剖宫产（CSD）婴儿的肠道微生物群组成和结构与阴道分娩（VD）婴儿不同， 和 减少， 和 增加。产后6个月时，纯母乳喂养恢复了这些由分娩方式引起的微生物变化，导致纯母乳喂养的VD和CSD婴儿肠道微生物特征相似（ = 0.57），而混合喂养的VD和CSD婴儿肠道微生物特征差异更大（ < 0.001）。我们发现，与VD相关的菌属在健康婴儿中富集，而与CSD相关的菌属在患有呼吸道感染的婴儿中富集。我们的研究结果表明，纯母乳喂养可能通过恢复剖宫产引起的肠道微生物群紊乱来降低婴儿呼吸道感染易感性，从而发挥促进健康的作用。
