Shanmuganathan Rajasree, Sathiyavimal Selvam, Hoang Le Quynh, M Al-Ansari Mysoon, A Al-Humaid Latifah, Jhanani G K, Lee Jintae, Barathi Selvaraj
School of Medicine and Pharmacy, Duy Tan University, Da Nang, Viet Nam; Institute of Research and Development, Duy Tan University, Da Nang, Viet Nam.
University Centre for Research & Development, Chandigarh University, Mohali, 140103, India.
Environ Res. 2023 Nov 1;236(Pt 1):116747. doi: 10.1016/j.envres.2023.116747. Epub 2023 Jul 26.
In the present study, cobalt oxide nanoparticles have been synthesized using the root extract of Curcuma longa in a manner that is both environmentally friendly and economical. Initially, the synthesized nanoparticles were characterized using a UV-Vis spectroscopy analysis, in which plasma resonance at 345 nm was observed, which confirmed that CL-Cobalt oxide nanoparticles were synthesized. While FTIR analysis showed a peak at 597.37 cm indicating Co-O stretching vibration. In addition, DLS, SEM and XRD analyses confirmed the synthesis of polydispersed (average size distribution of 97.5 ± 35.1 nm), cubic phase structure, and spherical-shaped CL-Cobalt oxide nanoparticles. CL-Cobalt oxide nanoparticles synthesized from green materials showed antioxidant and antimicrobial properties. CL-Cobalt oxide nanoparticles exhibited antibacterial activity against Gram negative (Klebsiella pneumoniae and Escherichia coli) and Gram positive bacteria (Bacillus subtilis, Staphylococcus aureus), while CL-Cobalt oxide nanoparticles additionally displayed significant antifungal activity against Aspergillus niger. CL-Cobalt oxide also showed application in a bioremediation perspective by showing strong photocatalytic degradation of methyl red, methyl orange and methyl blue dye. In addition, CL-Cobalt oxide also demonstrated anticancer activity against MDA-MB-468 cancer cell lines with an IC value of 150.8 μg/ml. Therefore, this is the first and foremost report on CL-Cobalt oxide nanoparticles synthesized using Curcuma longa showing antioxidant, antibacterial, antifungal, dye degradation and anticancer applications.
在本研究中，已使用姜黄的根提取物以既环保又经济的方式合成了氧化钴纳米颗粒。最初，使用紫外可见光谱分析对合成的纳米颗粒进行了表征，在该分析中观察到345nm处的等离子体共振，这证实了CL-氧化钴纳米颗粒已被合成。而傅里叶变换红外光谱分析显示在597.37cm处有一个峰，表明Co-O伸缩振动。此外，动态光散射、扫描电子显微镜和X射线衍射分析证实了多分散（平均尺寸分布为97.5±35.1nm）、立方相结构和球形CL-氧化钴纳米颗粒的合成。由绿色材料合成的CL-氧化钴纳米颗粒表现出抗氧化和抗菌性能。CL-氧化钴纳米颗粒对革兰氏阴性菌（肺炎克雷伯菌和大肠杆菌）和革兰氏阳性菌（枯草芽孢杆菌、金黄色葡萄球菌）表现出抗菌活性，而CL-氧化钴纳米颗粒还对黑曲霉显示出显著的抗真菌活性。CL-氧化钴从生物修复角度来看也有应用，它对甲基红、甲基橙和甲基蓝染料表现出很强的光催化降解作用。此外，CL-氧化钴对MDA-MB-468癌细胞系也表现出抗癌活性，IC值为150.8μg/ml。因此，这是关于使用姜黄合成CL-氧化钴纳米颗粒的首份也是最重要的一份报告，展示了其抗氧化、抗菌、抗真菌、染料降解和抗癌应用。
