Department of Psychiatry, Queen's University School of Medicine, Kingston, Ontario, Canada.
Psychiatr Clin North Am. 2023 Sep;46(3):463-473. doi: 10.1016/j.psc.2023.04.004. Epub 2023 May 27.
Depression is a disabling condition that often leads to significant burden. Women are more vulnerable to depression during reproductive-related "windows of vulnerability" such as the menopause transition and early postmenopausal years. This heightened vulnerability can be attributed, at least in part, to the neuromodulatory effects of estrogen on mood and cognition and the exposure to rapid fluctuations of estradiol levels during midlife years. The management of midlife depression can be challenging due to the presence and severity of other complaints such as vasomotor symptoms and sleep disturbances. Psychopharmacologic, behavioral, and hormonal interventions should be part of the treatment armamentarium.
抑郁症是一种使人丧失能力的疾病，往往会带来巨大的负担。女性在生殖相关的“脆弱期”，如更年期过渡和绝经早期，更容易患上抑郁症。这种更高的脆弱性至少部分归因于雌激素对情绪和认知的神经调节作用，以及在中年期间暴露于雌二醇水平的快速波动。由于存在血管舒缩症状和睡眠障碍等其他投诉，中年抑郁症的管理可能具有挑战性。精神药理学、行为和激素干预措施应该是治疗手段的一部分。
