信号淋巴细胞激活分子9（SIGLEC9）改变胶质母细胞瘤中的髓系平衡。 - Suppr | 超能文献

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SIGLEC9 tips the myeloid balance in glioblastoma.信号淋巴细胞激活分子9（SIGLEC9）改变胶质母细胞瘤中的髓系平衡。

Nat Cancer. 2023 Sep;4(9):1217-1219. doi: 10.1038/s43018-023-00603-1.

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The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression.Siglec7 和 Siglec9 在自然杀伤细胞对病毒感染和肿瘤进展中的作用。

J Immunol Res. 2020 Apr 6;2020:6243819. doi: 10.1155/2020/6243819. eCollection 2020.

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LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma.LINC01004-SPI1 轴激活肿瘤相关巨噬细胞中的 SIGLEC9，诱导食管鳞癌的放射抵抗和免疫抑制肿瘤微环境的形成。

Cancer Immunol Immunother. 2023 Jun;72(6):1835-1851. doi: 10.1007/s00262-022-03364-5. Epub 2023 Jan 23.

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Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency.信号淋巴细胞激活分子9（SIGLEC9）基因多态性对慢性阻塞性肺疾病（COPD）表型（包括急性加重频率）的影响。

Respirology. 2017 May;22(4):684-690. doi: 10.1111/resp.12952. Epub 2016 Nov 22.

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Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signalling.唾液酸结合免疫球蛋白样凝集素（Siglecs）：在细胞间相互作用和信号传导中的作用

Curr Opin Struct Biol. 2002 Oct;12(5):609-15. doi: 10.1016/s0959-440x(02)00375-5.

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Identification and validation of a siglec-based and aging-related 9-gene signature for predicting prognosis in acute myeloid leukemia patients.基于 Siglec 和衰老相关的 9 基因signature 鉴定及其在急性髓系白血病患者预后预测中的验证。

BMC Bioinformatics. 2022 Jul 19;23(1):284. doi: 10.1186/s12859-022-04841-5.

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[New insights into treatment of chronic obstructive pulmonary disease by targeting macrophages via sialic acid-binding immunoglobulin like lectin 9].[通过唾液酸结合免疫球蛋白样凝集素9靶向巨噬细胞治疗慢性阻塞性肺疾病的新见解]

Zhonghua Jie He He Hu Xi Za Zhi. 2021 Dec 12;44(12):1119-1123. doi: 10.3760/cma.j.cn112147-20211003-00694.

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Gene conversions are frequent but not under positive selection in the Siglec gene families of primates.基因转换在灵长类动物的唾液酸结合免疫球蛋白样凝集素（Siglec）基因家族中很常见，但不受正向选择作用。

Genome. 2014 Jun;57(6):317-25. doi: 10.1139/gen-2014-0083. Epub 2014 Aug 1.

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Siglecs in health and disease.健康与疾病中的唾液酸结合免疫球蛋白样凝集素

Mol Aspects Med. 2023 Apr;90:101147. doi: 10.1016/j.mam.2022.101147. Epub 2022 Oct 13.

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High Expression Levels of SIGLEC9 Indicate Poor Outcomes of Glioma and Correlate With Immune Cell Infiltration.SIGLEC9的高表达水平表明胶质瘤预后不良并与免疫细胞浸润相关。

Front Oncol. 2022 Jun 9;12:878849. doi: 10.3389/fonc.2022.878849. eCollection 2022.

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Comprehensive Analysis Identifies as a Potential Prognostic and Immunological Biomarker in Glioblastoma.综合分析确定为胶质母细胞瘤潜在的预后和免疫生物标志物。（你提供的原文中“Identifies”后缺少具体内容）

Cells. 2025 Jan 7;14(2):66. doi: 10.3390/cells14020066.

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Is modulation of immune checkpoints on glioblastoma-infiltrating myeloid cells a viable therapeutic strategy?调节胶质母细胞瘤浸润性髓样细胞上的免疫检查点是否是一种可行的治疗策略？

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本文引用的文献

1

Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response.Siglec-9 在胶质母细胞瘤的巨噬细胞上作为免疫检查点分子发挥作用，限制 T 细胞的启动和免疫治疗反应。

Nat Cancer. 2023 Sep;4(9):1273-1291. doi: 10.1038/s43018-023-00598-9. Epub 2023 Jul 17.

2

Intratumoral dendritic cell-CD4 T helper cell niches enable CD8 T cell differentiation following PD-1 blockade in hepatocellular carcinoma.肿瘤内树突状细胞-CD4+T 辅助细胞龛促进 PD-1 阻断后肝癌中 CD8+T 细胞的分化。

Nat Med. 2023 Jun;29(6):1389-1399. doi: 10.1038/s41591-023-02345-0. Epub 2023 Jun 15.

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