2:1 生酮饮食和低血糖指数饮食治疗慢性和发作性偏头痛：单中心真实世界回顾性研究。
2:1 ketogenic diet and low-glycemic-index diet for the treatment of chronic and episodic migraine: a single-center real-life retrospective study.
机构信息
Clinical Neurology Unit, Udine University Hospital, Piazzale Santa Maria della Misericordia 15, Udine, 33100, Italy.
Department of Medico-Surgical sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, 04100, Italy.
出版信息
J Headache Pain. 2023 Jul 28;24(1):95. doi: 10.1186/s10194-023-01635-9.
AIMS
The evidence supporting the efficacy of dietary preventive therapy in migraine is rising, particularly regarding the ketogenic diet. However, less evidence exists for the Low-Glycemic Index Diet and the 2:1 KD. This retrospective single-center real-life study aims to evaluate the efficacy of a 2:1 ketogenic diet and a Low-Glycemic-index Diet in chronic and high-frequency episodic migraine.
METHODS
Sixty patients with high-frequency episodic and chronic migraine were treated with either a Low-Glycemic-index diet (39 patients) or a 2:1 (21 patients) ketogenic diet for three months. We collected data on the migraine frequency and intensity and the MIDAS and HIT-6 scores through the headache diary. Anthropometric measurements (BMI, fat mass, free fat mass, and weight) were also collected and analyzed similarly. Data obtained at the baseline and after three months of each diet were compared.
RESULTS
Migraine intensity, frequency, MIDAS and HIT-6 scores, fat mass, weight, and BMI improved in both diet groups.
CONCLUSIONS
Both diets are effective in reducing migraine symptoms and migraine-related disability.
目的
支持饮食预防疗法在偏头痛中有效性的证据越来越多，特别是对于生酮饮食。然而，关于低升糖指数饮食和 2:1KD 的证据较少。本回顾性单中心真实世界研究旨在评估 2:1 生酮饮食和低升糖指数饮食在慢性和高频发作性偏头痛中的疗效。
方法
60 例高频发作性和慢性偏头痛患者接受低升糖指数饮食（39 例）或 2:1（21 例）生酮饮食治疗 3 个月。我们通过头痛日记收集偏头痛频率和强度以及 MIDAS 和 HIT-6 评分的数据。同样收集并分析了人体测量学测量值（BMI、脂肪量、游离脂肪量和体重）。比较了两种饮食方式在基线和 3 个月后的各项数据。
结果
两种饮食方式均能改善偏头痛强度、频率、MIDAS 和 HIT-6 评分、脂肪量、体重和 BMI。
结论
两种饮食方式均能有效减轻偏头痛症状和偏头痛相关残疾。
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