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TGF-β 促进牙髓干细胞的增殖和成骨分化：系统评价和荟萃分析。

TGF-β promotes the proliferation and osteogenic differentiation of dental pulp stem cells a systematic review and meta-analysis.

机构信息

Department of Stomatology, Bengbu Medical College, 2600 Donghai Avenue, Bengbu, 233030, China.

Center for Plastic & Reconstructive Surgery, Department of Stomatology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 310014, China.

出版信息

Eur J Med Res. 2023 Jul 27;28(1):261. doi: 10.1186/s40001-023-01227-y.

DOI:10.1186/s40001-023-01227-y
PMID:37501191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10373408/
Abstract

BACKGROUND

Dental pulp stem cells (DPSCs) are adult stem cells with multi-directional differentiation potential derived from ectoderm. Vitro experiments have shown that adding cytokines can help DPSCs to be transformed from multipotent stem cells to osteoblasts. TGF-β has been proved to have an effect on the proliferation and mineralization of bone tissue, but its effect on the osteogenesis and proliferation of dental pulp stem cells is still uncertain. We aim to determine the effect of TGF-β on the osteogenesis and proliferation of dental pulp stem cells.

METHODS

We have identified studies from the Cochrane Central Register of Controlled Trials, PubMed, Embase, and China national knowledge infrastructure (CNKI) for studies interested in TGF-β and proliferation and differentiation of dental pulp stem cells in the following indicators: A490 (an index for evaluating cell proliferation), bone sialoprotein (BSP), Col plasmid-1 (Col-1), osteocalcin (OCN), runt-related transcription factor 2 (Runx-2); and the number of mineralized nodules. Any language restrictions were rejected. Furthermore, we drew a forest plot for each outcome. We conducted a sensitivity analysis, data analysis, heterogeneity, and publication bias test. We evaluate the quality of each study under the guidance of Cochrane's tool for quality assessment.

RESULTS

The pooled data showed that TGF-β could promote the proliferation and ossification of dental pulp stem cells. All the included results support this conclusion except for the number of mineralized nodules: TGF-β increases the A490 index (SMD 3.11, 95% CI [0.54-5.69]), promotes the production of BSP (SMD 3.11, 95% CI [0.81-6.77]), promotes the expression of Col-1 (SMD 4.71, 95% CI [1.25-8.16]) and Runx-2 (SMD 3.37, 95% CI [- 0.63 to 7.36]), increases the content of OCN (SMD 4.32, 95% CI [1.20-7.44]) in dental pulp, and has no significant effect on the number of mineralized nodules (SMD 3.87, 95% CI [- 1.76 to 9.51]) in dental pulp stem cells.

CONCLUSIONS

TGF-β promotes the proliferation and osteogenesis of dental pulp stem cells.

摘要

背景

牙髓干细胞（DPSCs）是一种来源于外胚层的具有多向分化潜能的成体干细胞。体外实验表明，添加细胞因子有助于 DPSCs 从多能干细胞向成骨细胞转化。TGF-β 已被证明对骨组织的增殖和矿化有影响，但它对牙髓干细胞成骨和增殖的影响尚不确定。我们旨在确定 TGF-β 对牙髓干细胞成骨和增殖的影响。

方法

我们从 Cochrane 对照试验中心注册库、PubMed、Embase 和中国知网（CNKI）中确定了对 TGF-β 以及牙髓干细胞增殖和分化感兴趣的研究，以下指标为：A490（评估细胞增殖的指标）、骨涎蛋白（BSP）、Col 质粒-1（Col-1）、骨钙素（OCN）、 runt 相关转录因子 2（Runx-2）和矿化结节数。任何语言限制均被排除。此外，我们为每个结果绘制了森林图。我们进行了敏感性分析、数据分析、异质性和发表偏倚检验。我们根据 Cochrane 工具对每个研究的质量进行评估。

结果

汇总数据显示，TGF-β 可促进牙髓干细胞的增殖和矿化。所有纳入的结果均支持这一结论，除了矿化结节数外：TGF-β 增加 A490 指数（SMD3.11，95%CI[0.54-5.69]），促进 BSP 的产生（SMD3.11，95%CI[0.81-6.77]），促进 Col-1 的表达（SMD4.71，95%CI[1.25-8.16]）和 Runx-2（SMD3.37，95%CI[-0.63-7.36]），增加牙髓中 OCN 的含量（SMD4.32，95%CI[1.20-7.44]），对牙髓干细胞矿化结节数（SMD3.87，95%CI[-1.76-9.51]）无显著影响。

结论

TGF-β 促进牙髓干细胞的增殖和成骨。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f2b/10373408/20afbcb77b4a/40001_2023_1227_Fig13_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f2b/10373408/3ce931a213e1/40001_2023_1227_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f2b/10373408/e29c84fec945/40001_2023_1227_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f2b/10373408/104301897770/40001_2023_1227_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f2b/10373408/3fe02adddb9a/40001_2023_1227_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f2b/10373408/db357e571055/40001_2023_1227_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f2b/10373408/a839469b4d92/40001_2023_1227_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f2b/10373408/588c16d9c882/40001_2023_1227_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f2b/10373408/0551deae7637/40001_2023_1227_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f2b/10373408/edb737744d7b/40001_2023_1227_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f2b/10373408/d1343d317b0f/40001_2023_1227_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f2b/10373408/bed8abd1d895/40001_2023_1227_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f2b/10373408/60d4fb5cb749/40001_2023_1227_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f2b/10373408/20afbcb77b4a/40001_2023_1227_Fig13_HTML.jpg

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