酿酒酵母DNA连接酶缺陷型突变体cdc9的DNA修复能力。
The DNA repair capability of cdc9, the Saccharomyces cerevisiae mutant defective in DNA ligase.
作者信息
Johnston L H
出版信息
Mol Gen Genet. 1979 Feb 16;170(1):89-92. doi: 10.1007/BF00268583.
PMID:375019
Abstract
The cell cycle mutant, cdc9, in the yeast Saccharomyces cerevisiae is defective in DNA ligase be deficient in the repair of DNA damaged by methyl methane sulphonate. On the other hand survival of cdc9 after irradiation by gamma-rays is little different from that of the wild-type, even after a period of stress at the restrictive temperature. The mutant cdc9 is not allelic with any known rad or mms mutants.
摘要
酵母酿酒酵母中的细胞周期突变体cdc9在DNA连接酶方面存在缺陷，在修复甲磺酸甲酯损伤的DNA时存在不足。另一方面，即使在限制温度下经历一段时间的应激后，cdc9在γ射线照射后的存活率与野生型相比几乎没有差异。突变体cdc9与任何已知的rad或mms突变体都不等位。
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