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1
cdc9 ligase-defective mutants of Saccharomyces cerevisiae exhibit lowered resistance to lethal effects of bleomycin.酿酒酵母的cdc9连接酶缺陷型突变体对博来霉素的致死效应表现出较低的抗性。
J Bacteriol. 1982 Sep;151(3):1617-20. doi: 10.1128/jb.151.3.1617-1620.1982.
2
Bleomycin-induced DNA repair by Saccharomyces cerevisiae ATP-dependent polydeoxyribonucleotide ligase.博来霉素诱导酿酒酵母ATP依赖性多聚脱氧核糖核苷酸连接酶进行DNA修复。
J Bacteriol. 1988 Oct;170(10):4991-4. doi: 10.1128/jb.170.10.4991-4994.1988.
3
An improved assay for DNA ligase reveals temperature-sensitive activity in cdc9 mutants of Saccharomyces cerevisiae.一种改进的DNA连接酶检测方法揭示了酿酒酵母cdc9突变体中的温度敏感活性。
Mol Gen Genet. 1985;200(3):458-62. doi: 10.1007/BF00425731.
4
The DNA repair capability of cdc9, the Saccharomyces cerevisiae mutant defective in DNA ligase.酿酒酵母DNA连接酶缺陷型突变体cdc9的DNA修复能力。
Mol Gen Genet. 1979 Feb 16;170(1):89-92. doi: 10.1007/BF00268583.
5
Evidence that a single DNA ligase is involved in replication and recombination in yeast.有证据表明，单一的DNA连接酶参与酵母的复制和重组过程。
Proc Natl Acad Sci U S A. 1979 Sep;76(9):4586-8. doi: 10.1073/pnas.76.9.4586.
6
Enhanced mitotic recombination in a ligase-defective mutant of the yeast Saccharomyces cerevisiae.酿酒酵母连接酶缺陷型突变体中增强的有丝分裂重组。
Proc Natl Acad Sci U S A. 1979 Sep;76(9):4589-92. doi: 10.1073/pnas.76.9.4589.
7
The cdc9 ligase joins completed replicons in baker's yeast.
Mol Gen Genet. 1983;190(2):315-7. doi: 10.1007/BF00330657.
8
The effect of the cdc9 mutation on premeiotic DNA synthesis in the yeast Saccharomyces cerevisiae.cdc9突变对酿酒酵母减数分裂前DNA合成的影响。
Exp Cell Res. 1982 Sep;141(1):63-9. doi: 10.1016/0014-4827(82)90068-4.
9
Ligase-deficient yeast cells exhibit defective DNA rejoining and enhanced gamma ray sensitivity.连接酶缺陷型酵母细胞表现出DNA重新连接缺陷和γ射线敏感性增强。
J Bacteriol. 1982 Jun;150(3):1227-33. doi: 10.1128/jb.150.3.1227-1233.1982.
10
The use of a yeast strain with a temperature-sensitive DNA ligase to estimate DNA repair after exposure to mutagens.使用具有温度敏感性DNA连接酶的酵母菌株来评估暴露于诱变剂后的DNA修复情况。
Mutat Res. 1982 Apr;104(1-3):79-86. doi: 10.1016/0165-7992(82)90124-5.

引用本文的文献

1
Functional analysis of subcellular localization and protein-protein interaction sequences in the essential DNA ligase I protein of fission yeast.裂殖酵母必需DNA连接酶I蛋白中亚细胞定位和蛋白质-蛋白质相互作用序列的功能分析
Nucleic Acids Res. 2004 Jan 29;32(2):632-42. doi: 10.1093/nar/gkh199. Print 2004.
2
Potentiation of bleomycin cytotoxicity in Saccharomyces cerevisiae.博来霉素对酿酒酵母细胞毒性的增强作用。
Antimicrob Agents Chemother. 1994 Jul;38(7):1615-9. doi: 10.1128/AAC.38.7.1615.
3
Growth phase dependency of chromatin cleavage and degradation by bleomycin.博来霉素诱导的染色质切割与降解的生长阶段依赖性
Antimicrob Agents Chemother. 1989 Sep;33(9):1592-9. doi: 10.1128/AAC.33.9.1592.
4
Further characterizations of bleomycin-sensitive (blm) mutants of Saccharomyces cerevisiae with implications for a radiomimetic model.酿酒酵母博来霉素敏感（blm）突变体的进一步表征及其对放射模拟模型的意义。
J Bacteriol. 1991 Jun;173(11):3605-8. doi: 10.1128/jb.173.11.3605-3608.1991.

本文引用的文献

1
Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants.酵母细胞分裂周期的遗传控制：V. cdc 突变体的遗传分析。
Genetics. 1973 Jun;74(2):267-86. doi: 10.1093/genetics/74.2.267.
2
Ligase-deficient yeast cells exhibit defective DNA rejoining and enhanced gamma ray sensitivity.连接酶缺陷型酵母细胞表现出DNA重新连接缺陷和γ射线敏感性增强。
J Bacteriol. 1982 Jun;150(3):1227-33. doi: 10.1128/jb.150.3.1227-1233.1982.
3
Modulation of bleomycin cytotoxicity.博来霉素细胞毒性的调节
Antimicrob Agents Chemother. 1982 Apr;21(4):595-600. doi: 10.1128/AAC.21.4.595.
4
DNA polymerase III-dependent repair synthesis in response to bleomycin in toluene-treated Escherichia coli.甲苯处理的大肠杆菌中响应博来霉素的DNA聚合酶III依赖性修复合成
Mol Gen Genet. 1980;179(3):595-605. doi: 10.1007/BF00271750.
5
Macromolecule synthesis in temperature-sensitive mutants of yeast.酵母温度敏感突变体中的大分子合成
J Bacteriol. 1967 May;93(5):1662-70. doi: 10.1128/jb.93.5.1662-1670.1967.
6
Genetic control of the cell division cycle in yeast. 3. Seven genes controlling nuclear division.酵母细胞分裂周期的遗传控制。3. 七个控制核分裂的基因。
Exp Cell Res. 1971 Aug;67(2):389-401. doi: 10.1016/0014-4827(71)90424-1.
7
DNA ligase mutants of Escherichia coli.大肠杆菌的DNA连接酶突变体
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1580-7. doi: 10.1073/pnas.67.3.1580.
8
Properties of a deoxyribonucleic acid ligase mutant of Escherichia coli: x-ray sensitivity.大肠杆菌脱氧核糖核酸连接酶突变体的特性：对X射线敏感。
J Bacteriol. 1970 May;102(2):588-9. doi: 10.1128/jb.102.2.588-589.1970.
9
Characterization of bleomycin-resistant DNA.博来霉素抗性DNA的特性分析
Biophys J. 1973 Dec;13(12):1296-306. doi: 10.1016/s0006-3495(73)86063-1.
10
Action of bleomycin on DNA and RNA.博来霉素对DNA和RNA的作用。
Eur J Biochem. 1972 Dec 18;31(3):518-25. doi: 10.1111/j.1432-1033.1972.tb02560.x.

酿酒酵母的cdc9连接酶缺陷型突变体对博来霉素的致死效应表现出较低的抗性。

cdc9 ligase-defective mutants of Saccharomyces cerevisiae exhibit lowered resistance to lethal effects of bleomycin.

作者信息

Moore C W

出版信息

J Bacteriol. 1982 Sep;151(3):1617-20. doi: 10.1128/jb.151.3.1617-1620.1982.

DOI:10.1128/jb.151.3.1617-1620.1982
PMID:6179928
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC220448/
Abstract

Conditional ligase-deficient mutants of Saccharomyces cerevisiae were more sensitive than their parental (CDC9) strain to dose-dependent killing by bleomycin, even when mutant cells were pregrown and exposed to the antibiotic at permissive temperatures. Pretreatment incubation at the restrictive temperature (37 degrees C) under growing or nongrowing conditions enhanced bleomycin killing of both cdc9-1 and cdc9-9 mutants. This sensitization could be relieved by incubation at the permissive temperature before treatment.

摘要

酿酒酵母的条件性连接酶缺陷型突变体比其亲本（CDC9）菌株对博来霉素的剂量依赖性杀伤更敏感，即使突变细胞在允许温度下预培养并暴露于抗生素中也是如此。在生长或非生长条件下于限制温度（37摄氏度）进行预处理孵育，可增强博来霉素对cdc9 - 1和cdc9 - 9突变体的杀伤作用。这种敏感性可通过在处理前于允许温度下孵育来缓解。