Curcumin-reduced gold nanoparticles facilitate delivery to a cervical cancer cell model.

To synthesize curcumin-reduced gold nanoparticles (AuNPs) for the efficient delivery to and expression of the gene in cervical cancer (HeLa) cells . Curcumin-reduced AuNPs were synthesized, stabilized with poly-L-lysine and PEG, conjugated to DNA and physicochemically characterized. Cytotoxicity and expression were accessed . Stable, spherical AuNPs effectively compacted and protected the DNA and tolerated well . Real-time quantitative PCR and ELISA confirmed the successful delivery and expression of the gene in HeLa cells. The favorable attributes of this AuNP-delivery system and the significant expression obtained augur well for cytokine-based therapy or immunotherapy in cervical cancer.