Biomedical Science, Faculty of Health and Society, and Biofilms Research Center, Malmö University, 205 06 Malmö, Sweden.
Biosensors (Basel). 2023 Jul 7;13(7):717. doi: 10.3390/bios13070717.
An electronic tongue is a powerful analytical instrument based on an array of non-selective chemical sensors with a partial specificity for data gathering and advanced pattern recognition methods for data analysis. Connecting electronic tongues with electrochemical techniques for data collection has led to various applications, mostly within sensing for food quality and environmental monitoring, but also in biomedical research for the analyses of different bioanalytes in human physiological fluids. In this paper, an electronic tongue consisting of six electrodes (viz., gold, platinum, palladium, titanium, iridium, and glassy carbon) was designed and tested in authentic (undiluted, unpretreated) human saliva samples from eight volunteers, collected before and during the COVID-19 pandemic. Investigations of 11 samples using differential pulse voltammetry and a principal component analysis allowed us to distinguish between SARS-CoV-2-free and infected authentic human saliva. This work, as a proof-of-principle demonstration, provides a new perspective for the use of electronic tongues in the field of enzyme-free electrochemical biosensing, highlighting their potential for future applications in non-invasive biomedical analyses.
电子舌是一种基于阵列式非选择性化学传感器的强大分析仪器，具有针对数据采集的部分特异性和用于数据分析的先进模式识别方法。将电子舌与电化学技术相结合进行数据收集，已经导致了各种应用，主要集中在食品质量传感和环境监测方面，但也在生物医学研究中用于分析人体生理液中的不同生物分析物。在本文中，设计并测试了一种由六个电极（即金、铂、钯、钛、铱和玻碳）组成的电子舌，该电子舌取自 8 位志愿者在 COVID-19 大流行前后未经稀释和预处理的真实（未稀释、未经预处理）人唾液样本。使用差分脉冲伏安法和主成分分析对 11 个样本进行的研究，使我们能够区分 SARS-CoV-2 阴性和阳性的真实人类唾液。这项工作作为原理验证演示，为电子舌在无酶电化学生物传感领域的应用提供了新的视角，突出了它们在未来非侵入性生物医学分析中的应用潜力。
