基于羟基化黑磷/聚-L-赖氨酸复合材料的马拉硫磷超灵敏电化学生物传感
Ultrasensitive Electrochemical Aptasensing of Malathion Based on Hydroxylated Black Phosphorus/Poly-L-Lysine Composite.
机构信息
Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou 412007, China.
Institute for Future Sciences, University of South, Changsha 410000, China.
出版信息
Biosensors (Basel). 2023 Jul 16;13(7):735. doi: 10.3390/bios13070735.
A highly sensitive unlabeled electrochemical aptasensor based on hydroxylated black phosphorus/poly-L-lysine (hBP/PLL) composite is introduced herein for the detection of malathion. Poly-L-lysine (PLL) with adhesion and coating properties adhere to the surface of the nanosheets by noncovalent interactions with underlying hydroxylated black phosphorus nanosheets (hBP) to produce the hBP/PLL composite. The as-synthesized hBP/PLL composite bonded to Au nanoparticles (Au NPs) firmly by assembling and using them as a substrate for the aptamer with high specificity as a probe to fabricate the sensor. Under optimal conditions, the linear range of the electrochemical aptasensor was 0.1 pM~1 μM, and the detection limit was 2.805 fM. The electrochemical aptasensor has great selectivity, a low detection limit, and anti-interference, which has potential application prospects in the field of rapid trace detection of pesticide residues.
本文介绍了一种基于羟基化黑磷/聚-L-赖氨酸（hBP/PLL）复合材料的高灵敏无标记电化学适体传感器，用于检测马拉硫磷。具有粘附和涂层性能的聚-L-赖氨酸（PLL）通过与基底羟基化黑磷纳米片（hBP）的非共价相互作用附着在纳米片的表面上，从而产生 hBP/PLL 复合材料。合成的 hBP/PLL 复合材料通过组装牢固地结合到金纳米颗粒（Au NPs）上，并将其用作具有高特异性的适体的基底作为探针来制备传感器。在最佳条件下，电化学适体传感器的线性范围为 0.1 pM~1 μM，检测限为 2.805 fM。电化学适体传感器具有良好的选择性、低检测限和抗干扰性，在农药残留的快速痕量检测领域具有潜在的应用前景。
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