Ryzer Danielle, Bhatti Bushra, Streicher Alana, Weinberg Paula, Hanna Fady, Moretto Jessica, Brooks Dina, Quach Shirley, Oliveira Ana
School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.
Respiratory Research, West Park Healthcare Center, Toronto, ON, Canada.
JMIR Res Protoc. 2023 Jul 28;12:e48235. doi: 10.2196/48235.
Chronic respiratory diseases (CRDs) may cause reduced oxygen availability to organs and body tissues, leading to an increased risk for ischemic damage, which can result in brain tissue injury. This damage can lead to a myriad of neurological symptoms contributing to cognitive decline. Cognitive interventions may attenuate cognitive deficits in people with CRDs; however, the effects have not yet been systematically summarized in the literature.
The purpose of this systematic review is to assess the effects of cognitive interventions (including cognitive behavioral therapy and transcranial brain stimulation) on cognitive function (primary outcome), HRQL, self-management, symptoms, physical activity, physical function, ability to complete activities of daily living (ADLs), hospital admissions, functional capacity, functional performance, psychological and social outcomes, exacerbations, healthcare utilization, and survival in individuals with CRDs.
This review will be conducted in accordance with the Cochrane handbook for systematic reviews of interventions and reported following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Searches will be performed in MEDLINE, Embase, Emcare, PsycINFO, Scopus, and CINAHL. Articles will be included if they focus on the effects of cognitive interventions on adults with CRDs, are published in peer-reviewed journals, and are written in English, French, or Portuguese. Risk of bias will be evaluated with the Cochrane Risk of Bias 2 tool for randomized controlled trials, and the Risk of Bias in Non-randomized Studies of Interventions tool for nonrandomized studies. Meta-analyses will be performed if at least 2 studies provided sufficient data for a specific outcome. The GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) assessment will be used to evaluate the overall quality of the evidence.
This systematic review was initiated in November 2022 and registered with PROSPERO in February 2023, prior to title and abstract screening. Full-text screening of articles will be completed in June 2023. Data extraction and drafting of the manuscript will occur from July 2023 to August 2023, with expected publication in February 2024.
This systematic review will summarize the effects of cognitive interventions on cognitive function in people with CRDs. It will guide health care professionals in selecting evidence-based strategies to enhance cognitive well-being and overall health outcomes for individuals with CRDs. Additionally, it will identify research gaps and highlight areas for future exploration, supporting researchers in advancing knowledge in this field.
PROSPERO CRD42023396234; https://tinyurl.com/mwjrfbxv.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/48235.
慢性呼吸道疾病（CRDs）可能导致器官和身体组织的氧气供应减少，增加缺血性损伤风险，进而导致脑组织损伤。这种损伤可引发一系列神经症状，导致认知能力下降。认知干预可能会减轻CRDs患者的认知缺陷；然而，相关影响尚未在文献中得到系统总结。
本系统评价旨在评估认知干预（包括认知行为疗法和经颅脑刺激）对CRDs患者认知功能（主要结局）、健康相关生活质量（HRQL）、自我管理、症状、身体活动、身体功能、完成日常生活活动（ADLs）的能力、住院、功能能力、功能表现、心理和社会结局、病情加重、医疗保健利用及生存的影响。
本评价将按照Cochrane干预措施系统评价手册进行，并依据PRISMA（系统评价和Meta分析的首选报告项目）指南进行报告。将在MEDLINE、Embase、Emcare、PsycINFO、Scopus和CINAHL中进行检索。如果文章关注认知干预对成年CRDs患者的影响、发表在同行评审期刊且为英文、法文或葡萄牙文撰写，则纳入研究。将使用Cochrane随机对照试验偏倚风险2工具评估随机对照试验的偏倚风险，使用非随机干预研究中的偏倚风险工具评估非随机研究的偏倚风险。如果至少有2项研究为特定结局提供了充分数据，将进行Meta分析。将使用GRADE（推荐分级、评估、制定和评价）评估来评价证据的总体质量。
本系统评价于2022年11月启动，并于2023年2月在PROSPERO注册，先于标题和摘要筛选。文章的全文筛选将于2023年6月完成。数据提取和稿件起草将于2023年7月至8月进行，预计于2024年2月发表。
本系统评价将总结认知干预对CRDs患者认知功能的影响。它将指导医疗保健专业人员选择基于证据的策略，以提高CRDs患者的认知健康和整体健康结局。此外，它将识别研究差距并突出未来探索的领域，支持研究人员推进该领域的知识。
PROSPERO CRD42023396234；https://tinyurl.com/mwjrfbxv。
国际注册报告识别号（IRRID）：PRR1-10.2196/48235。
