Georgiou Stefanos G, Sideri Aikaterini I, Anagnostou Tilemachos L, Gouletsou Pagona G, Tsioli Vassiliki G, Galatos Apostolos D
Clinic of Surgery, Faculty of Veterinary Science, School of Health Sciences, University of Thessaly, 43100 Karditsa, Greece.
Anaesthesia and Intensive Care Unit, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece.
Vet Sci. 2023 Jul 3;10(7):433. doi: 10.3390/vetsci10070433.
The main objective of this prospective, randomized, blind, cross-over experimental study was to evaluate the effect of classical music on the depth of sedation and propofol requirements for the induction of anaesthesia in dogs. Twenty dogs were involved, and each was subjected to three different treatments with a 3-month gap: Chopin music, Mozart music, and no music, via loudspeakers. The dogs were premedicated with acepromazine and butorphanol by intramuscular injection, and anaesthesia was induced using propofol intravenously. To compare the depth of sedation and propofol requirements for the induction of anaesthesia among the different treatments, we utilized non-parametric tests (Kruskal-Wallis test) for the depth of sedation due to a slight deviation from the normal distribution and parametric (ANOVA) for propofol requirements. When exposed to music (Chopin or Mozart), dogs exhibited deeper sedation and required less propofol for their intubation compared to the no-music treatment ( < 0.05). Exposure to classical music had a positive impact on the level of sedation, and more profound central nervous system depression seemed to contribute to approximately 20% lower propofol dose requirements for tracheal intubation. Therefore, classical music during the preoperative period appeared to exert a beneficial effect, at least when applying the specific pre-anaesthetic medications used in the present study.
这项前瞻性、随机、盲法、交叉实验研究的主要目的是评估古典音乐对犬类麻醉诱导时镇静深度和丙泊酚需求量的影响。共有20只犬参与实验，每只犬在间隔3个月的时间里接受三种不同的处理：通过扬声器播放肖邦音乐、莫扎特音乐以及不播放音乐。犬只通过肌肉注射乙酰丙嗪和布托啡诺进行预处理，然后静脉注射丙泊酚诱导麻醉。为了比较不同处理之间麻醉诱导时的镇静深度和丙泊酚需求量，由于镇静深度略有偏离正态分布，我们对其采用非参数检验（Kruskal-Wallis检验），对丙泊酚需求量采用参数检验（方差分析）。与不播放音乐的处理相比，当犬只暴露于音乐（肖邦或莫扎特）中时，表现出更深的镇静效果，并且插管时所需的丙泊酚更少（P<0.05）。暴露于古典音乐对镇静水平有积极影响，更深度的中枢神经系统抑制似乎导致气管插管所需的丙泊酚剂量降低约20%。因此，术前播放古典音乐似乎产生了有益效果，至少在应用本研究中使用的特定麻醉前用药时是这样。
