Gezhouba Central Hospital of the Third Clinical Medical College of Three Gorges University, Yichang, Hubei, 443002, China.
Experimental and Practical Teaching Center, Hubei College of Chinese Medicine, Jingzhou, Hubei, 434000, China.
Environ Res. 2023 Dec 15;239(Pt 1):116751. doi: 10.1016/j.envres.2023.116751. Epub 2023 Jul 27.
Oral cavity carcinomas are the most frequent malignancies among head and neck malignancies. Oral tumors include not only oral cancer cells with different potency and stemness but also consist of diverse cells, containing anticancer immune cells, stromal and also immunosuppressive cells that influence the immune system reactions. The infiltrated T and natural killer (NK) cells are the substantial tumor-suppressive immune compartments in the tumor. The infiltration of these cells has substantial impacts on the response of tumors to immunotherapy, chemotherapy, and radiotherapy. Nevertheless, cancer cells, stromal cells, and some other compartments like regulatory T cells (Tregs), macrophages, and myeloid-derived suppressor cells (MDSCs) can repress the immune responses against malignant cells. Boosting anticancer immunity by inducing the immune system or repressing the tumor-promoting cells is one of the intriguing approaches for the eradication of malignant cells such as oral cancers. This review aims to concentrate on the secretions and interactions in the oral tumor immune microenvironment. We review targeting tumor stroma, immune system and immunosuppressive interactions in oral tumors. This review will also focus on therapeutic targets and therapeutic agents such as nanoparticles and products with anti-tumor potency that can boost anticancer immunity in oral tumors. We also explain possible future perspectives including delivery of various cells, natural products and drugs by nanoparticles for boosting anticancer immunity in oral tumors.
口腔癌是头颈部恶性肿瘤中最常见的恶性肿瘤。口腔肿瘤不仅包括具有不同潜能和干性的口腔癌细胞，还包含多种细胞，其中包括抗癌免疫细胞、基质细胞和免疫抑制细胞，这些细胞会影响免疫系统的反应。浸润的 T 细胞和自然杀伤 (NK) 细胞是肿瘤中重要的肿瘤抑制性免疫细胞群。这些细胞的浸润对肿瘤对免疫疗法、化疗和放疗的反应有重大影响。然而，癌细胞、基质细胞以及其他一些细胞群，如调节性 T 细胞 (Tregs)、巨噬细胞和髓源性抑制细胞 (MDSCs)，可以抑制针对恶性细胞的免疫反应。通过诱导免疫系统或抑制肿瘤促进细胞来增强抗癌免疫是消除恶性细胞（如口腔癌）的一种有趣方法。本综述旨在关注口腔肿瘤免疫微环境中的分泌和相互作用。我们综述了靶向肿瘤基质、免疫系统和免疫抑制性相互作用在口腔肿瘤中的应用。本综述还将重点介绍治疗靶点和治疗剂，如纳米颗粒和具有抗肿瘤活性的产品，它们可以增强口腔肿瘤中的抗癌免疫。我们还解释了包括通过纳米颗粒递送来增强口腔肿瘤中的抗癌免疫的各种细胞、天然产物和药物的可能未来前景。
