Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, 6 Yothi Rd. Ratchathewi, Bangkok, 10400, Thailand.
Development of Disease Management Model for Oral Cancer with an Integration Network of Screening, Surveillance, and Treatment from Primary Care Unit to Tertiary Care in Nakhonratchasima Province Project, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
BMC Oral Health. 2023 Jul 28;23(1):527. doi: 10.1186/s12903-023-03198-2.
Certain evidence indicated high prevalence of Candida in oral potentially malignant disorders (OPMDs) and oral cancer (OC). This study was aimed to investigate the presence of Candida and its associated factors in participants who attended the oral cancer screening program in the lower northeastern districts of Thailand.
Convenient participants residing in the lower northeastern districts of Thailand who attended the oral cancer screening were enrolled. A questionnaire retrieving demographic characteristics, risk factors of oral cancer, and risk of having Candida was completed. Oral examination was performed by oral medicine specialists or oral surgeons. The participants were categorized into 4 groups according to their clinical diagnosis, namely normal oral mucosa (NOM), OPMDs/OC, non-OPMDs/OC and clinically suspected oral candidiasis (CSOC). Stimulated saliva flow rate was measured. Dip-slide test was performed in each participant to evaluate the presence of Candida. The levels of Candida were categorized into high and low levels according to the score received from the dip-slide test. Factors associated with high levels of Candida were identified using multivariate logistic regression analysis.
A total of 577 participants were recruited. High levels of Candida were found in 31.3%, 24.7%, 25.9% and 18.1% in the OPMDs/OC, the non-OPMDs/OC, the CSOC and the NOM groups, respectively. According to multivariate logistic regression analysis, age above 60 years, female gender, betel quid chewing habit, use of denture, hyposalivation, and being in the CSOC group were found to be significantly associated with high levels of Candida.
Higher number of participants in the OPMDs/OC group was found to have high levels of Candida. Increasing age, female gender, betel quid chewing habit, use of denture, hyposalivation and having CSOC lesions were associated with high levels of Candida.
有证据表明，口腔潜在恶性疾病（OPMDs）和口腔癌（OC）中念珠菌的患病率较高。本研究旨在调查泰国东北部低地地区参加口腔癌筛查计划的参与者中念珠菌的存在及其相关因素。
便利招募居住在泰国东北部低地地区并参加口腔癌筛查的参与者。完成了一份问卷，以获取人口统计学特征、口腔癌危险因素和念珠菌感染风险的信息。由口腔医学专家或口腔外科医生进行口腔检查。根据临床诊断，将参与者分为 4 组，分别为正常口腔黏膜（NOM）、OPMDs/OC、非 OPMDs/OC 和临床疑似口腔念珠菌病（CSOC）。测量刺激唾液流率。对每位参与者进行滴片试验以评估念珠菌的存在。根据滴片试验的得分，将念珠菌水平分为高水平和低水平。使用多变量逻辑回归分析确定与高水平念珠菌相关的因素。
共招募了 577 名参与者。OPMDs/OC、非 OPMDs/OC、CSOC 和 NOM 组中高水平念珠菌的检出率分别为 31.3%、24.7%、25.9%和 18.1%。多变量逻辑回归分析显示，年龄 60 岁以上、女性、咀嚼槟榔习惯、使用义齿、唾液分泌减少和 CSOC 组与高水平念珠菌显著相关。
OPMDs/OC 组中发现更多的参与者具有高水平的念珠菌。年龄增长、女性、咀嚼槟榔习惯、使用义齿、唾液分泌减少和 CSOC 病变与高水平念珠菌相关。
