在鼠伤寒沙门氏菌的一个组氨酸营养缺陷型中，肼作为诱变剂。

Hydrazines as mutagens in a histidine-requiring auxotroph of Salmonella typhimurium.

作者信息

Tosk J, Schmeltz I, Hoffmann D

出版信息

Mutat Res. 1979 Mar;66(3):247-52. doi: 10.1016/0165-1218(79)90085-5.

Abstract

Hydrazines have been found naturally in tobacco and mushrooms. Other hydrazines are used in industry, medicine, and agriculture. Although about 38 hydrazines are carcinogenic, few, if any, have been tested successfully in rapid bacterial mutagenesis assays. We have utilized a tester strain of Salmonella typhimurium (TA1530) in order to determine the mutagenic activity of a number of hydrazines and related compounds. This strain is thus shown to be effective as a tester organism for the facile detection of hydrazines as mutagens.

摘要

人们已在烟草和蘑菇中发现了天然存在的肼。其他肼类化合物用于工业、医药和农业。虽然约38种肼类具有致癌性，但在快速细菌诱变试验中成功进行测试的却寥寥无几。我们利用鼠伤寒沙门氏菌（TA1530）测试菌株来测定多种肼类及相关化合物的诱变活性。结果表明，该菌株作为测试生物体，能有效便捷地检测出肼类的诱变剂。