Pinto Pereira Snehal M, Nugawela Manjula D, McOwat Kelsey, Dalrymple Emma, Xu Laila, Ladhani Shamez N, Simmons Ruth, Chalder Trudie, Swann Olivia, Ford Tamsin, Heyman Isobel, Segal Terry, Semple Malcolm G, Rojas Natalia K, Shafran Roz, Stephenson Terence
Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, London WC1E 6BT, UK.
UCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Children (Basel). 2023 Jul 14;10(7):1227. doi: 10.3390/children10071227.
Although 99% of children and young people have been exposed to SARS-CoV-2, the long-term prevalence of post-COVID-19 symptoms in young people is unclear. The aim of this study is to describe symptom profiles 12 months after SARS-CoV-2 testing.
A matched cohort study of a national sample of 20,202 children and young people who took a SARS-CoV-2 PCR test between September 2020 and March 2021.
12 months post-index-test, there was a difference in the number of symptoms reported by initial negatives who never tested positive (NN) compared to the other three groups who had at least one positive test ( < 0.001). Similarly, 10.2% of the NN group described five-plus symptoms at 12 months compared to 15.9-24.0% in the other three groups who had at least one positive test. The most common symptoms were tiredness, sleeping difficulties, shortness of breath, and headaches for all four groups. For all these symptoms, the initial test positives with subsequent reports of re-infection had higher prevalences than other positive groups ( < 0.001). Symptom profiles, mental health, well-being, fatigue, and quality of life did not vary by vaccination status.
Following the pandemic, many young people, particularly those that have had multiple SARS-CoV-2 positive tests, experience a range of symptoms that warrant consideration and potential investigation and intervention.
尽管99%的儿童和年轻人都接触过新冠病毒，但年轻人感染新冠病毒后症状的长期流行情况尚不清楚。本研究的目的是描述新冠病毒检测12个月后的症状特征。
对2020年9月至2021年3月期间接受新冠病毒PCR检测的20202名儿童和年轻人的全国样本进行匹配队列研究。
在索引测试后12个月，从未检测呈阳性的初始阴性者（NN）报告的症状数量与至少有一次检测呈阳性的其他三组相比存在差异（<0.001）。同样，NN组中10.2%的人在12个月时描述有五种及以上症状，而至少有一次检测呈阳性的其他三组中这一比例为15.9%-24.0%。所有四组中最常见的症状是疲劳、睡眠困难、呼吸急促和头痛。对于所有这些症状，最初检测呈阳性且随后报告再次感染的人比其他阳性组的患病率更高（<0.001）。症状特征、心理健康、幸福感、疲劳和生活质量不因疫苗接种状况而有所不同。
疫情之后，许多年轻人，尤其是那些多次新冠病毒检测呈阳性的人，会出现一系列症状，值得关注并可能进行调查和干预。
