Boicean Adrian, Birsan Sabrina, Ichim Cristian, Boeras Ioana, Roman-Filip Iulian, Blanca Grama, Bacila Ciprian, Fleaca Radu Sorin, Dura Horatiu, Roman-Filip Corina
Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.
Molecular Biology Laboratory of the Applied Ecology Research Center, Faculty of Sciences, Lucian Blaga University of Sibiu, 550012 Sibiu, Romania.
Biomedicines. 2023 Jul 21;11(7):2058. doi: 10.3390/biomedicines11072058.
At present, it is necessary to identify specific biochemical, molecular, and genetic markers that can reliably aid in screening digestive cancer and correlate with the degree of disease development. Has-miR-129-5p is a small, non-coding molecule of RNA, circulating in plasma, gastric juice, and other biological fluids; it plays a protective role in tumoral growth, metastasis, etc. Furthermore, it is involved in various diseases, from the development of digestive cancer in cases of downregulation to neurodegenerative diseases and depression. Methods: We examined meta-analyses, research, and studies related to miR-129-5-p involved in digestive cancer and its implications in cancer processes, as well as metastasis, and described its implications in neurological diseases. Conclusions: Our review outlines that miR-129-5p is a significant controller of different pathways, genes, and proteins and influences different diseases. Some important pathways include the WNT and PI3K/AKT/mTOR pathways; their dysregulation results in digestive neoplasia and neurodegenerative diseases.
目前，有必要确定能够可靠地辅助筛查消化道癌症并与疾病发展程度相关的特定生化、分子和遗传标志物。Has-miR-129-5p是一种小的非编码RNA分子，存在于血浆、胃液和其他生物体液中循环；它在肿瘤生长、转移等过程中发挥保护作用。此外，它还参与各种疾病，从下调时消化道癌症的发生到神经退行性疾病和抑郁症。方法：我们研究了与miR-129-5-p参与消化道癌症及其在癌症过程以及转移中的影响相关的荟萃分析、研究和报告，并描述了其在神经疾病中的影响。结论：我们的综述概述了miR-129-5p是不同途径、基因和蛋白质的重要调控因子，并影响不同疾病。一些重要途径包括WNT和PI3K/AKT/mTOR途径；它们的失调会导致消化道肿瘤和神经退行性疾病。
