Long non-coding RNA enhances gastric carcinoma proliferation, migration and invasion via the miR-136-5p/HOXC10 axis.

Known as long non-coding RNAs (lncRNAs), they are essential in regulating tumour metastasis. In gastric carcinoma (GC), lncRNA cytoskeleton regulator () keeps at high levels, but its influences on GC cell proliferation, migration and invasion need further investigation. Hence, the role played by lncRNA in GC was explored in this study. We employed quantitative reverse transcription PCR (RT-qPCR) to determine lncRNA and microRNA (miR)-136-5p levels in GC, Western blot analysis to measure Homeobox C10 (), and Flow cytometry, transwell, and cell counting kit-8 (CCK-8) assays to evaluate the roles played by miR-136-5p and lncRNA in GC cells. Furthermore, bioinformatics analysis and Luciferase assay were carried out to identify the target genes of the two. LncRNA was found to be upregulated in GC cells, and its knockdown inhibited GC cell growth. MiR-136-5p, underexpressed in GC cells, was identified as a target of in modulating GC progression. Moreover, was miR-136-5p's downstream target. Finally, participated in GC progression in vivo. Collectively, modulates the miR-136-5p/HOXC10 axis to accelerate GC progression.