Marcut Lavinia, Manescu Paltanea Veronica, Antoniac Aurora, Paltanea Gheorghe, Robu Alina, Mohan Aurel George, Grosu Elena, Corneschi Iuliana, Bodog Alin Danut
Faculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, RO-410073 Oradea, Romania.
Intensive Care Unit, Clinical Emergency Hospital Oradea, 65 Gheorghe Doja Street, RO-410169 Oradea, Romania.
Materials (Basel). 2023 Jul 17;16(14):5034. doi: 10.3390/ma16145034.
Ventilator-associated pneumonia is one of the most frequently encountered hospital infections and is an essential issue in the healthcare field. It is usually linked to a high mortality rate and prolonged hospitalization time. There is a lack of treatment, so alternative solutions must be continuously sought. The endotracheal tube is an indwelling device that is a significant culprit for ventilator-associated pneumonia because its surface can be colonized by different types of pathogens, which generate a multispecies biofilm. In the paper, we discuss the definition of ventilator-associated pneumonia, the economic burdens, and its outcomes. Then, we present the latest technological solutions for endotracheal tube surfaces, such as active antimicrobial coatings, passive coatings, and combinatorial methods, with examples from the literature. We end our analysis by identifying the gaps existing in the present research and investigating future possibilities that can decrease ventilator-associated pneumonia cases and improve patient comfort during treatment.
呼吸机相关性肺炎是最常见的医院感染之一，也是医疗领域的一个重要问题。它通常与高死亡率和延长的住院时间相关。由于缺乏有效的治疗方法，因此必须不断寻求替代解决方案。气管内导管是一种留置装置，是呼吸机相关性肺炎的一个重要致病因素，因为其表面可被不同类型的病原体定植，从而形成多物种生物膜。在本文中，我们讨论了呼吸机相关性肺炎的定义、经济负担及其后果。然后，我们介绍了气管内导管表面的最新技术解决方案，如活性抗菌涂层、被动涂层和组合方法，并引用了文献中的实例。我们通过找出当前研究中存在的差距，并探讨未来可减少呼吸机相关性肺炎病例并提高治疗期间患者舒适度的可能性，来结束我们的分析。
