Lokhov Petr G, Balashova Elena E, Trifonova Oxana P, Maslov Dmitry L, Plotnikova Oksana A, Sharafetdinov Khaider K, Nikityuk Dmitry B, Tutelyan Victor A, Ponomarenko Elena A, Archakov Alexander I
Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Federal Research Centre of Nutrition, Biotechnology and Food Safety, Russian Academy of Sciences, Ustinsky Passage 2/14, 109240 Moscow, Russia.
Metabolites. 2023 Jun 27;13(7):798. doi: 10.3390/metabo13070798.
Recently, the concept of a mass spectrometric blood metabogram was introduced, which allows the analysis of the blood metabolome in terms of the time, cost, and reproducibility of clinical laboratory tests. It was demonstrated that the components of the metabogram are related groups of the blood metabolites associated with humoral regulation; the metabolism of lipids, carbohydrates, and amines; lipid intake into the organism; and liver function, thereby providing clinically relevant information. The purpose of this work was to evaluate the relevance of using the metabogram in a disease. To do this, the metabogram was used to analyze patients with various degrees of metabolic alterations associated with obesity. The study involved 20 healthy individuals, 20 overweight individuals, and 60 individuals with class 1, 2, or 3 obesity. The results showed that the metabogram revealed obesity-associated metabolic alterations, including changes in the blood levels of steroids, amino acids, fatty acids, and phospholipids, which are consistent with the available scientific data to date. Therefore, the metabogram allows testing of metabolically unhealthy overweight or obese patients, providing both a general overview of their metabolic alterations and detailing their individual characteristics. It was concluded that the metabogram is an accurate and clinically applicable test for assessing an individual's metabolic status in disease.
最近，质谱血液代谢图谱的概念被提出，它能在临床实验室检测的时间、成本和可重复性方面对血液代谢组进行分析。结果表明，代谢图谱的组成部分是与体液调节、脂质、碳水化合物和胺类代谢、机体脂质摄入以及肝功能相关的血液代谢物组群，从而提供临床相关信息。这项工作的目的是评估在疾病中使用代谢图谱的相关性。为此，代谢图谱被用于分析患有与肥胖相关的不同程度代谢改变的患者。该研究纳入了20名健康个体、20名超重个体以及60名患有1级、2级或3级肥胖的个体。结果显示，代谢图谱揭示了与肥胖相关的代谢改变，包括血液中类固醇、氨基酸、脂肪酸和磷脂水平的变化，这与目前已有的科学数据一致。因此，代谢图谱能够检测代谢不健康的超重或肥胖患者，既提供其代谢改变的总体概况，又详述其个体特征。得出的结论是，代谢图谱是评估疾病中个体代谢状态的一种准确且临床适用的检测方法。
