Grandinetti Roberto, Palazzolo Elisabetta, Rizzo Luisa, Carbone Roberta, Pisi Giovanna, Fainardi Valentina, Esposito Susanna
Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Microorganisms. 2023 Jul 4;11(7):1745. doi: 10.3390/microorganisms11071745.
The clinical aspects of SARS-CoV-2 infection, as well as the COVID-19 vaccines' safety, efficacy and effectiveness in pediatric patients with asthma, are crucial to adapting clinical management in this fragile population and for prevention strategies. The aim of this narrative review was to evaluate the impact of SARS-CoV-2 infection in children with asthma and the impact of COVID-19 vaccination. Systematic research using the principal medical databases was conducted using specific search query strings from the early spreading of COVID-19 globally until March 2023; further relevant data were drawn from the main national and supranational institutions. No significant differences in SARS-CoV-2 incidence and morbidity were found in asthmatic pediatric patients compared to non-asthmatic ones; however, subjects with uncontrolled asthma were found to be at increased risk of developing a serious disease during SARS-CoV-2 infection. Regarding COVID-19 vaccines, accumulating data support their safety, efficacy and effectiveness on asthmatic children regardless of asthma severity. Further cohort-based studies are needed as the evidence of new epidemic waves caused by new viral variants makes the current knowledge outdated.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的临床情况，以及新冠病毒疾病（COVID-19）疫苗在哮喘儿童患者中的安全性、有效性和效力，对于调整这一脆弱人群的临床管理以及预防策略至关重要。本叙述性综述的目的是评估SARS-CoV-2感染对哮喘儿童的影响以及COVID-19疫苗接种的影响。使用主要医学数据库进行了系统研究，搜索查询字符串从COVID-19在全球早期传播至2023年3月；还从主要国家和超国家机构获取了进一步的相关数据。与非哮喘儿童相比，哮喘儿童患者中SARS-CoV-2的发病率和患病率未发现显著差异；然而，发现哮喘控制不佳的患者在SARS-CoV-2感染期间发生严重疾病的风险增加。关于COVID-19疫苗，越来越多的数据支持其对哮喘儿童的安全性、有效性和效力，无论哮喘严重程度如何。由于新病毒变种引发新疫情浪潮的证据使现有知识过时，因此需要进一步开展基于队列的研究。
