Department of Biochemistry and Molecular Biology/Bioagro, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa 36570.000, MG, Brazil.
Viruses. 2023 Jul 21;15(7):1593. doi: 10.3390/v15071593.
Begomoviruses, which belong to the family, are intracellular parasites transmitted by whiteflies to dicotyledonous plants thatsignificantly damage agronomically relevant crops. These nucleus-replicating DNA viruses move intracellularly from the nucleus to the cytoplasm and then, like other plant viruses, cause disease by spreading systemically throughout the plant. The transport proteins of begomoviruses play a crucial role in recruiting host components for the movement of viral DNA within and between cells, while exhibiting functions that suppress the host's immune defense. Pioneering studies on species of the genus have identified specific viral transport proteins involved in intracellular transport, cell-to-cell movement, and systemic spread. Recent research has primarily focused on viral movement proteins and their interactions with the cellular host transport machinery, which has significantly expanded understanding on viral infection pathways. This review focuses on three components within this context: (i) the role of viral transport proteins, specifically movement proteins (MPs) and nuclear shuttle proteins (NSPs), (ii) their ability to recruit host factors for intra- and intercellular viral movement, and (iii) the suppression of antiviral immunity, with a particular emphasis on bipartite begomoviral movement proteins.
双生病毒属于 科，是通过粉虱传播给双子叶植物的细胞内寄生虫，会严重损害具有重要经济价值的作物。这些在细胞核内复制的 DNA 病毒在细胞内从细胞核移动到细胞质，然后像其他植物病毒一样，通过在植物体内系统性传播而引起疾病。双生病毒的转运蛋白在病毒 DNA 在细胞内和细胞间的运动中招募宿主成分方面发挥着关键作用，同时表现出抑制宿主免疫防御的功能。对 属种的开创性研究已经确定了参与细胞内运输、细胞间运动和系统传播的特定病毒转运蛋白。最近的研究主要集中在病毒运动蛋白及其与细胞宿主运输机制的相互作用上，这极大地扩展了对病毒感染途径的理解。本文综述了这一背景下的三个组成部分：(i)病毒转运蛋白，特别是运动蛋白 (MPs) 和核穿梭蛋白 (NSPs) 的作用，(ii)它们招募宿主因子进行细胞内和细胞间病毒运动的能力，以及 (iii)抗病毒免疫的抑制作用，特别强调二分体双生病毒运动蛋白。
