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2018-2021 年保加利亚流行的鼻病毒基因型。

Rhinovirus Genotypes Circulating in Bulgaria, 2018-2021.

机构信息

Department of Virology, National Centre of Infectious and Parasitic Diseases, 1233 Sofia, Bulgaria.

Clinic of Infectious Diseases, University Hospital "Prof. Dr. Stoyan Kirkovich" AD, 6003 Stara Zagora, Bulgaria.

出版信息

Viruses. 2023 Jul 22;15(7):1608. doi: 10.3390/v15071608.

DOI:10.3390/v15071608
PMID:37515294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10385483/
Abstract

Rhinoviruses (RV) are one of the most common causative agents of respiratory infections, with significant socioeconomic impact. RV infections are not notifiable in Bulgaria, and little is known about the different RV genotypes circulating in the country. This study aims to investigate the diversity of RV genotypes that were circulating in Bulgaria in the period 2018-2021 in samples from ILI/ARI patients. Genotype assignment was based on sequencing and phylogenetic analysis of the 5' untranslated region and the VP4-VP2 region. Out of a total of 1385 nasopharyngeal swabs tested, 166 were RV-positive (RV detection rate: 11.99% (166/1385)). Those with a cycle threshold <25 were selected for genotyping (n = 63). RV isolates were successfully genotyped and classified into 34 genotypes within (RV-A) (RV-B) and (RV-C) species. Presumptive recombination events between the 5'UTR and VP4-VP2 regions were detected in three of the isolates. RV-A and RV-C were the prevalent RV species, with significantly more frequent detections of RV-A in the years before the COVID-19 pandemic compared to the post-pandemic period, when RV-C prevailed. The present study is the first to determine RV genotypes in Bulgaria and the circulation of RV-C has been described for the first time in the country.

摘要

鼻病毒（RV）是引起呼吸道感染的最常见病原体之一，对社会经济有重大影响。保加利亚对 RV 感染不进行报告，对该国流行的不同 RV 基因型知之甚少。本研究旨在调查 2018 年至 2021 年期间保加利亚 ILI/ARI 患者样本中循环的 RV 基因型多样性。基于 5'非翻译区和 VP4-VP2 区的测序和系统进化分析进行基因型分配。在总共检测的 1385 个鼻咽拭子中，166 个为 RV 阳性（RV 检出率：11.99%（166/1385））。选择循环阈值<25 的样本进行基因分型（n=63）。成功对 RV 分离株进行了基因分型，并在 （RV-A）、 （RV-B）和 （RV-C）种内分为 34 种基因型。在三个分离株中检测到 5'UTR 和 VP4-VP2 区之间的推定重组事件。RV-A 和 RV-C 是流行的 RV 物种，与 COVID-19 大流行前相比，RV-A 的检测频率明显更高，而在大流行后，RV-C 则占主导地位。本研究首次确定了保加利亚的 RV 基因型，并首次描述了该国 RV-C 的流行情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5def/10385483/9cb9f7e84206/viruses-15-01608-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5def/10385483/52a18d668c11/viruses-15-01608-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5def/10385483/f02bac9f283c/viruses-15-01608-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5def/10385483/9cb9f7e84206/viruses-15-01608-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5def/10385483/52a18d668c11/viruses-15-01608-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5def/10385483/f02bac9f283c/viruses-15-01608-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5def/10385483/9cb9f7e84206/viruses-15-01608-g003.jpg

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