Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Department of Radiology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
J Magn Reson Imaging. 2024 May;59(5):1758-1768. doi: 10.1002/jmri.28907. Epub 2023 Jul 29.
To explore whether MR fingerprinting (MRF) scans provide motion-robust and quantitative brain tissue measurements for non-sedated infants with prenatal opioid exposure (POE).
Prospective.
13 infants with POE (3 male; 12 newborns (age 7-65 days) and 1 infant aged 9-months).
FIELD STRENGTH/SEQUENCE: 3T, 3D T1-weighted MPRAGE, 3D T2-weighted TSE and MRF sequences.
The image quality of MRF and MRI was assessed in a fully crossed, multiple-reader, multiple-case study. Sixteen image quality features in three types-image artifacts, structure and myelination visualization-were ranked by four neuroradiologists (8, 7, 5, and 8 years of experience respectively), using a 3-point scale. MRF T1 and T2 values in 8 white matter brain regions were compared between babies younger than 1 month and babies between 1 and 2 months.
Generalized estimating equations model to test the significance of differences of regional T1 and T2 values of babies under 1 month and those older. MRI and MRF image quality was assessed using Gwet's second order auto-correlation coefficient (AC) with confidence levels. The Cochran-Mantel-Haenszel test was used to assess the difference in proportions between MRF and MRI for all features and stratified by the type of features. A P value <0.05 was considered statistically significant.
The MRF of two infants were excluded in T1 and T2 value analysis due to severe motion artifact but were included in the image quality assessment. In infants under 1 month of age (N = 6), the T1 and T2 values were significantly higher compared to those between 1 and 2 months of age (N = 4). MRF images showed significantly higher image quality ratings in all three feature types compared to MRI images.
MR Fingerprinting scans have potential to be a motion-robust and efficient method for nonsedated infants.
2 TECHNICAL EFFICACY STAGE: 1.
探讨磁共振指纹成像（MRF）扫描是否可为产前阿片类药物暴露（POE）的非镇静婴儿提供运动稳健且定量的脑组织测量。
前瞻性研究。
13 名 POE 婴儿（3 名男性；12 名新生儿（7-65 天龄）和 1 名 9 月龄婴儿）。
场强/序列：3T，3D T1 加权 MPRAGE，3D T2 加权 TSE 和 MRF 序列。
在完全交叉、多读者、多病例研究中评估了 MRF 和 MRI 的图像质量。四位神经放射科医生（分别具有 8、7、5 和 8 年的经验）使用 3 分制对三种类型的图像质量特征（图像伪影、结构和髓鞘可视化）进行了排名。比较了 8 个白质脑区的 MRF T1 和 T2 值，这些婴儿小于 1 个月和 1-2 个月。
广义估计方程模型用于检验小于 1 个月和大于 1 个月婴儿的区域 T1 和 T2 值差异的显著性。使用 Gwet 二阶自相关系数（AC）评估 MRI 和 MRF 图像质量，并具有置信水平。使用 Cochran-Mantel-Haenszel 检验评估 MRF 和 MRI 之间所有特征的比例差异，并按特征类型进行分层。P 值<0.05 被认为具有统计学意义。
由于严重的运动伪影，有两名婴儿的 MRF T1 和 T2 值分析被排除，但纳入了图像质量评估。在 1 个月以下的婴儿（N=6）中，T1 和 T2 值明显高于 1-2 个月的婴儿（N=4）。MRF 图像在所有三种特征类型中均显示出明显更高的图像质量评分，而 MRI 图像则显示出明显更高的图像质量评分。
MRF 扫描有可能成为非镇静婴儿的一种运动稳健且高效的方法。
2 技术功效阶段：1.
