College of Textiles & Clothing, Qingdao University, Qingdao, 266071, China.
Shandong Academy of Pharmaceutical Science, Jinan, 250101, China.
Acta Biomater. 2023 Sep 15;168:78-112. doi: 10.1016/j.actbio.2023.07.041. Epub 2023 Jul 28.
As one of the long-established and necessary medical devices, surgical sutures play an essentially important role in the closing and healing of damaged tissues and organs postoperatively. The recent advances in multiple disciplines, like materials science, engineering technology, and biomedicine, have facilitated the generation of various innovative surgical sutures with humanization and multi-functionalization. For instance, the application of numerous absorbable materials is assuredly a marvelous progression in terms of surgical sutures. Moreover, some fantastic results from recent laboratory research cannot be ignored either, ranging from the fiber generation to the suture structure, as well as the suture modification, functionalization, and even intellectualization. In this review, the suture materials, including natural or synthetic polymers, absorbable or non-absorbable polymers, and metal materials, were first introduced, and then their advantages and disadvantages were summarized. Then we introduced and discussed various fiber fabrication strategies for the production of surgical sutures. Noticeably, advanced nanofiber generation strategies were highlighted. This review further summarized a wide and diverse variety of suture structures and further discussed their different features. After that, we covered the advanced design and development of surgical sutures with multiple functionalizations, which mainly included surface coating technologies and direct drug-loading technologies. Meanwhile, the review highlighted some smart and intelligent sutures that can monitor the wound status in a real-time manner and provide on-demand therapies accordingly. Furthermore, some representative commercial sutures were also introduced and summarized. At the end of this review, we discussed the challenges and future prospects in the field of surgical sutures in depth. This review aims to provide a meaningful reference and guidance for the future design and fabrication of innovative surgical sutures. STATEMENT OF SIGNIFICANCE: This review article introduces the recent advances of surgical sutures, including material selection, fiber morphology, suture structure and construction, as well as suture modification, functionalization, and even intellectualization. Importantly, some innovative strategies for the construction of multifunctional sutures with predetermined biological properties are highlighted. Moreover, some important commercial suture products are systematically summarized and compared. This review also discusses the challenges and future prospects of advanced sutures in a deep manner. In all, this review is expected to arouse great interest from a broad group of readers in the fields of multifunctional biomaterials and regenerative medicine.
作为一种历史悠久且必不可少的医疗器械，外科缝线在术后受损组织和器官的闭合和愈合中起着至关重要的作用。近年来，材料科学、工程技术和生物医学等多个学科的进步，促进了各种具有人性化和多功能化的创新外科缝线的产生。例如，可吸收材料的应用无疑是外科缝线的一个巨大进步。此外，最近实验室研究的一些出色成果也不容忽视，从纤维的产生到缝线的结构，以及缝线的改性、功能化，甚至智能化。在这篇综述中，首先介绍了缝线材料，包括天然或合成聚合物、可吸收或不可吸收聚合物以及金属材料，然后总结了它们的优缺点。然后介绍并讨论了用于生产外科缝线的各种纤维制造策略。值得注意的是，高级纳米纤维制造策略得到了强调。本综述进一步总结了广泛多样的缝线结构，并进一步讨论了它们的不同特点。之后，我们介绍并讨论了具有多种功能化的外科缝线的高级设计和开发，主要包括表面涂层技术和直接载药技术。同时，该综述强调了一些智能和智能缝线，这些缝线可以实时监测伤口状况，并相应地提供按需治疗。此外，还介绍和总结了一些有代表性的商业缝线。在这篇综述的最后，我们深入讨论了外科缝线领域的挑战和未来前景。本文旨在为创新外科缝线的未来设计和制造提供有意义的参考和指导。
意义声明： 本文介绍了外科缝线的最新进展，包括材料选择、纤维形态、缝线结构和构造，以及缝线改性、功能化，甚至智能化。重要的是，强调了一些用于构建具有预定生物学特性的多功能缝线的创新策略。此外，系统地总结和比较了一些重要的商业缝线产品。本文还深入讨论了先进缝线的挑战和未来前景。总之，预计这篇综述将引起多功能生物材料和再生医学领域广大读者的极大兴趣。
