Feng Lijuan, Chen Qianjuan, Huang Linjie, Long Liling
Department of Radiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Gaungxi Medical University, Ministry of Education, Nanning, Guangxi, China.
Front Oncol. 2023 Jul 13;13:1194200. doi: 10.3389/fonc.2023.1194200. eCollection 2023.
To examine the methodological quality of radiomics-related studies and evaluate the ability of radiomics to predict treatment response to transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).
A systematic review was performed on radiomics-related studies published until October 15, 2022, predicting the effectiveness of TACE for HCC. Methodological quality and risk of bias were assessed using the Radiomics Quality Score (RQS) and Quality Assessment of Diagnostic Accuracy Studies-2 tools, respectively. Pooled sensitivity, pooled specificity, and area under the curve (AUC) were determined to evaluate the utility of radiomics in predicting the response to TACE for HCC.
In this systematic review, ten studies were eligible, and six of these studies were used in our meta-analysis. The RQS ranged from 7-21 (maximum possible score: 36). The pooled sensitivity and specificity were 0.89 (95% confidence interval (CI) = 0.79-0.95) and 0.82 (95% CI = 0.64-0.92), respectively. The overall AUC was 0.93 (95% CI = 0.90-0.95).
Radiomics-related studies evaluating the efficacy of TACE in patients with HCC revealed promising results. However, prospective and multicenter trials are warranted to make radiomics more feasible and acceptable.
探讨放射组学相关研究的方法学质量，并评估放射组学预测肝细胞癌（HCC）经动脉化疗栓塞术（TACE）治疗反应的能力。
对截至2022年10月15日发表的预测TACE治疗HCC疗效的放射组学相关研究进行系统评价。分别使用放射组学质量评分（RQS）和诊断准确性研究质量评估-2工具评估方法学质量和偏倚风险。确定合并敏感性、合并特异性和曲线下面积（AUC），以评估放射组学在预测HCC对TACE反应中的效用。
在本系统评价中，有10项研究符合条件，其中6项研究用于我们的荟萃分析。RQS范围为7-21（最高可能分数：36）。合并敏感性和特异性分别为0.89（95%置信区间（CI）=0.79-0.95）和0.82（95%CI=0.64-0.92）。总体AUC为0.93（95%CI=0.90-0.95）。
评估TACE对HCC患者疗效的放射组学相关研究显示出有前景的结果。然而，需要进行前瞻性多中心试验，以使放射组学更可行和可接受。
