Soheilipour Maryam, Tabesh Elham, Najmi Soheila, Raisi Mostafa, Adibi Peyman
Isfahan Gastroenterology and Hepatology Research Center (IGHRC), Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Caspian J Intern Med. 2023 Summer;14(3):518-525. doi: 10.22088/cjim.14.3.518.
Functional abdominal bloating is one of the functional gastrointestinal disorders (FGIDs). Here, we aimed to investigate and compare the effects of probiotics and colloidal bismuth subcitrate on abdominal bloating.
This was a double-blinded randomized clinical trial performed on 125 patients with functional abdominal bloating in Isfahan in 2020-2021. At the beginning of the study, information on the frequency of abdominal bloating, its severity, the occurrence of early satiety, frequency of borborygmus, frequency of belching, and the frequency of defecation per week was collected. Patients were divided into 3 groups receiving familact probiotic pills that contained 7 bacterial strains, colloidal bismuth subcitrate tablets, and placebo pills for 4 weeks. Afterwards, the frequency and severity of abdominal bloating and other symptoms were compared.
After 2 weeks, patients in the probiotic group had a significantly lower frequency of abdominal bloating compared to other groups (P= 0.006). After 4 and 8 weeks, patients in the probiotic group and bismuth group had a lower frequency of bloating )3.18±3.02, 4.11±3.34) compared to placebo (5.10±3.54) (P= 0.001 and P= 0.037, respectively). During the study, patients in the probiotic group had a significantly lower bloating severity (41.90% had no symptom) compared to bismuth and placebo groups (12.50 ,12.00% had no symptom) (p< 0.05). The frequency of borborygmus was significantly lower in the probiotic group after 2 and 4 weeks during the study compared to other groups (1.62±0.2 Vs 2.69±0.3, 2.45±0.3 ) (P= 0.010 and P= 0.013, respectively).
According to our data, consumption of probiotics improves the frequency and severity of abdominal bloating and reduces borborygmus. Colloidal bismuth subcitrate also has significant effects.
功能性腹胀是功能性胃肠病（FGIDs）之一。在此，我们旨在研究和比较益生菌与枸橼酸铋钾对腹胀的影响。
这是一项于2020 - 2021年在伊斯法罕对125例功能性腹胀患者进行的双盲随机临床试验。在研究开始时，收集了关于腹胀频率、严重程度、早饱发生情况、肠鸣音频率、嗳气频率以及每周排便频率的信息。患者被分为3组，分别接受含有7种菌株的复合益生菌丸、枸橼酸铋钾片和安慰剂丸，为期4周。之后，比较腹胀及其他症状的频率和严重程度。
2周后，益生菌组患者的腹胀频率显著低于其他组（P = 0.006）。4周和8周后，益生菌组和铋剂组患者的腹胀频率（分别为3.18±3.02、4.11±3.34）低于安慰剂组（5.10±3.54）（P分别为0.001和0.037）。在研究期间，益生菌组患者的腹胀严重程度显著低于铋剂组和安慰剂组（分别有41.90%、12.50%、12.00%无症状）（p < 0.05）。在研究期间，2周和4周后，益生菌组的肠鸣音频率显著低于其他组（分别为1.62±0.2对2.69±0.3、2.45±0.3）（P分别为0.010和0.013）。
根据我们的数据，食用益生菌可改善腹胀的频率和严重程度，并减少肠鸣音。枸橼酸铋钾也有显著效果。
