Gastroenterology Institute, Hillel Yaffe Medical Center, Hadera, Israel.
Gastroenterology Institute, Nazareth EMMS Hospital, Nazareth, Israel.
Adv Ther. 2019 May;36(5):1075-1084. doi: 10.1007/s12325-019-00924-7. Epub 2019 Mar 16.
Functional abdominal bloating and distension (FABD) are common gastrointestinal complaints, encountered on a daily basis by gastroenterologists and healthcare providers. Functional abdominal bloating is a subjective sensation that is commonly associated with an objective abdominal distension. FABD may be diagnosed as a single entity (the sole or cardinal complaint) or may overlap with other functional gastrointestinal disorders such as functional constipation, irritable bowel syndrome, and functional dyspepsia. The pathophysiology of FABD is not completely understood. Proposed underlying mechanisms include visceral hypersensitivity, behavioral induced abnormal abdominal wall-phrenic reflexes, the effect of poorly absorbed fermentable carbohydrates, and microbiome alterations. Management includes behavioral therapy, dietary interventions, microbiome modulation, and medical therapy. This review presents the current knowledge on the pathophysiology, evaluation, and management of FABD.
功能性腹胀和腹部膨隆（FABD）是常见的胃肠道主诉，每天都会被胃肠病学家和医疗保健提供者遇到。功能性腹胀是一种主观感觉，通常与客观的腹部膨隆有关。FABD 可被诊断为单一实体（唯一或主要主诉），也可与其他功能性胃肠道疾病重叠，如功能性便秘、肠易激综合征和功能性消化不良。FABD 的病理生理学尚未完全了解。提出的潜在机制包括内脏高敏性、行为引起的异常腹壁-膈反射、吸收不良的可发酵碳水化合物的影响以及微生物组的改变。治疗包括行为疗法、饮食干预、微生物组调节和药物治疗。这篇综述介绍了 FABD 的病理生理学、评估和管理的最新知识。
