Sridhar Jayavel, Parit Rahul, Boopalakrishnan Govindaraju, Rexliene M Johni, Praveen Rajkumar, Viswananathan Balaji
Department of Biotechnology (DDE), Madurai Kamaraj University, Madurai, 625021, Tamilnadu, India.
Case Stud Chem Environ Eng. 2022 Dec;6:100241. doi: 10.1016/j.cscee.2022.100241. Epub 2022 Aug 1.
Coronavirus disease caused by the SARS-CoV-2 virus has emerged as a global challenge in terms of health and disease monitoring. COVID-19 infection is mainly spread through the SARS-CoV-2 infection leading to the development of mild to severe clinical manifestations. The virus binds to its cognate receptor ACE2 which is widely expressed among different tissues in the body. Notably, SARS-CoV-2 shedding in the fecal samples has been reported through the screening of sewage water across various countries. Wastewater screening for the presence of SARS-CoV-2 provides an alternative method to monitor infection threat, variant identification, and clinical evaluation to restrict the virus progression. Multiple cohort studies have reported the application of wastewater treatment approaches and epidemiological significance in terms of virus monitoring. Thus, the manuscript outlines consolidated and systematic information regarding the application of wastewater-based epidemiology in terms of monitoring and managing a viral disease outbreak like COVID-19.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒引起的冠状病毒病已成为健康和疾病监测方面的一项全球性挑战。新型冠状病毒肺炎（COVID-19）感染主要通过SARS-CoV-2感染传播，导致从轻症到重症的临床表现。该病毒与其同源受体血管紧张素转换酶2（ACE2）结合，ACE2在体内不同组织中广泛表达。值得注意的是，通过对各国污水的筛查，已报告粪便样本中有SARS-CoV-2脱落。对污水中SARS-CoV-2的筛查提供了一种监测感染威胁、变异株鉴定和临床评估的替代方法，以限制病毒的传播。多项队列研究报告了废水处理方法的应用及其在病毒监测方面的流行病学意义。因此，本文概述了基于废水的流行病学在监测和管理像COVID-19这样的病毒性疾病暴发方面的综合系统信息。
