Erickson Claire M, Chin Nathaniel A, Rosario Hannah L, Peterson Amanda, Johnson Sterling C, Clark Lindsay R
Department of Medical Ethics and Health Policy University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA.
Department of Medicine Division of Geriatrics & Gerontology University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.
Alzheimers Dement (N Y). 2023 Jul 29;9(3):e12413. doi: 10.1002/trc2.12413. eCollection 2023 Jul-Sep.
Increased availability of Alzheimer's disease (AD) biomarker tests provides older adults with opportunities to seek out and learn results. We evaluated the feasibility of virtually returning AD biomarker results.
Trained study clinicians disclosed amyloid positron emission tomography (PET) results and provided dementia risk-reduction counseling via televideo to cognitively unimpaired participants already enrolled in AD research ( = 99; mean age ± SD: 72.0 ± 4.8; 67% women; 95% White; 28% amyloid elevated).
Our study demonstrated acceptable levels of retention (93%), compliance (98%), adherence (98%), clinician competence (97%), education comprehension (quiz scores 14/15), and virtual visit functionality (rating 9.4/10). Depression, anxiety, and suicidality remained low and did not differ by amyloid result.
Virtual return of amyloid PET results to cognitively unimpaired research participants is feasible and does not result in increased psychological symptoms. Technological barriers for some participants highlight the need for flexibility. These findings support the use of televideo in AD biomarker disclosure, although our study sample and design have important limitations for generalizability.
阿尔茨海默病（AD）生物标志物检测的可及性增加，为老年人提供了获取和了解检测结果的机会。我们评估了虚拟反馈AD生物标志物结果的可行性。
训练有素的研究临床医生通过视频向已参与AD研究的认知未受损参与者披露淀粉样蛋白正电子发射断层扫描（PET）结果，并提供痴呆症风险降低咨询（n = 99；平均年龄±标准差：72.0±4.8；67%为女性；95%为白人；28%淀粉样蛋白升高）。
我们的研究显示出可接受的保留率（93%）、依从性（98%）、坚持性（98%）、临床医生能力（97%）、教育理解度（测验分数14/15）和虚拟就诊功能（评分9.4/10）。抑郁、焦虑和自杀倾向仍然较低，且不因淀粉样蛋白结果而异。
向认知未受损的研究参与者虚拟反馈淀粉样蛋白PET结果是可行的，且不会导致心理症状增加。一些参与者面临的技术障碍凸显了灵活性的必要性。这些发现支持在AD生物标志物披露中使用视频，尽管我们的研究样本和设计在普遍性方面存在重要局限性。
