糖化血清蛋白水平作为妊娠期糖尿病的筛查和诊断试验

Glycosylated serum protein level as a screening and diagnostic test for gestational diabetes mellitus.

作者信息

Bourgeois F J, Harbert G M, Paulsen E P, Thiagarajah S

出版信息

Am J Obstet Gynecol. 1986 Sep;155(3):493-6. doi: 10.1016/0002-9378(86)90263-2.

Abstract

Glycosylated serum protein assay was examined as an alternative to standard glucose screening and glucose tolerance testing. In a comparison of two groups of gravid women having abnormal 1-hour 50 gm glucose screening tests, there was no difference in glycosylated protein level in the group with abnormal glucose tolerance test results (9.4% +/- 2.0%, mean +/- SD; n = 8) versus normal results (9.2% +/- 1.07%, mean +/- SD; n = 11). Furthermore, correlation of glycosylated serum protein level with glucose screening test results was poor (r = 0.185, p = 0.23, n = 17). Glycosylated serum protein assay is not useful in detecting mild metabolic aberrations associated with gestational diabetes.

摘要

对糖化血清蛋白检测作为标准葡萄糖筛查和葡萄糖耐量试验的替代方法进行了研究。在两组1小时50克葡萄糖筛查试验异常的孕妇中，葡萄糖耐量试验结果异常组（9.4%±2.0%，均值±标准差；n = 8）与正常结果组（9.2%±1.07%，均值±标准差；n = 11）的糖化蛋白水平没有差异。此外，糖化血清蛋白水平与葡萄糖筛查试验结果的相关性较差（r = 0.185，p = 0.23，n = 17）。糖化血清蛋白检测对于检测与妊娠期糖尿病相关的轻度代谢异常没有用处。